Molecular Profile Detail


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Profile Name EML4 - ALK ALK F1174V ALK L1196M
Gene Variant Detail

ALK F1174V (gain of function - predicted)

ALK L1196M (gain of function - predicted)

EML4 - ALK (gain of function)

Relevant Treatment Approaches


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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
EML4 - ALK ALK F1174V ALK L1196M Advanced Solid Tumor resistant Lorlatinib Preclinical - Cell culture Actionable In a preclinical study, ALK F1174V was identified as a compound mutation in transformed cells expressing ALK L1196M in the context of EML4-ALK that acquired resistance to Lorlatinib (PF-06463922) in culture (PMID: 29650534). 29650534
Clinical Trial Phase Therapies Title Recruitment Status