Gene Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, variants, or PubMed publications.

Have questions, comments or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Gene Symbol FBXW7
Synonyms AGO | CDC4 | FBW6 | FBW7 | FBX30 | FBXO30 | FBXW6 | hAgo | hCdc4 | SEL-10 | SEL10
Gene Description FBXW7, F-box/WD repeat-containing protein 7, is part of the SCF E3 ubiquitin-protein ligase complex, which plays a role in the degradation of proteins involved in cell division and cell growth (PMID: 17909001, PMID: 22673505). FBXW7 mutations have been associated with cholangiocarcinoma and acute lymphocytic leukemia (PMID: 17909001) and have been identified in many other cancers, including colorectal (PMID: 28424412), endometrial, and stomach cancer (PMID: 17909001).

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
FBXW7 A481V unknown
FBXW7 A503T unknown
FBXW7 A503V unknown
FBXW7 C386W unknown
FBXW7 D135Y unknown
FBXW7 D362* loss of function - predicted
FBXW7 D440N unknown
FBXW7 D480N loss of function - predicted
FBXW7 D480Y unknown
FBXW7 D520N unknown
FBXW7 D550Mfs*6 unknown
FBXW7 D560G unknown
FBXW7 D600H unknown
FBXW7 D600Y unknown
FBXW7 del loss of function mTORC1 Inhibitor
FBXW7 E113D unknown
FBXW7 E117del unknown
FBXW7 E192A unknown
FBXW7 E248D unknown
FBXW7 E287V unknown
FBXW7 E369* loss of function - predicted mTORC1 Inhibitor
FBXW7 G16delinsVR no effect - predicted
FBXW7 G397D unknown
FBXW7 G411S unknown
FBXW7 G422C unknown
FBXW7 G423* loss of function - predicted mTORC1 Inhibitor
FBXW7 G423R unknown
FBXW7 G423V loss of function
FBXW7 G437E unknown
FBXW7 G437R unknown
FBXW7 G437V unknown
FBXW7 G477S unknown
FBXW7 G499Vfs*25 loss of function - predicted mTORC1 Inhibitor
FBXW7 G517E unknown
FBXW7 G579W unknown
FBXW7 G597E unknown
FBXW7 G667fs unknown
FBXW7 G670fs unknown
FBXW7 H379R unknown
FBXW7 H382N unknown
FBXW7 H420Y unknown
FBXW7 H460R loss of function - predicted mTORC1 Inhibitor
FBXW7 H460Y unknown
FBXW7 H470P unknown
FBXW7 H500D unknown
FBXW7 H500R unknown
FBXW7 H500Y unknown
FBXW7 I347M unknown
FBXW7 I435fs loss of function - predicted mTORC1 Inhibitor
FBXW7 I563T unknown
FBXW7 inact mut loss of function mTORC1 Inhibitor
FBXW7 K11R loss of function - predicted mTORC1 Inhibitor
FBXW7 K167T unknown
FBXW7 K239Q unknown
FBXW7 K299fs loss of function - predicted mTORC1 Inhibitor
FBXW7 K404E unknown
FBXW7 K444fs loss of function - predicted mTORC1 Inhibitor
FBXW7 L301P unknown
FBXW7 L320I unknown
FBXW7 L443H unknown
FBXW7 loss loss of function mTORC1 Inhibitor
FBXW7 mutant unknown
FBXW7 P247T unknown
FBXW7 P285H unknown
FBXW7 P298L unknown
FBXW7 Q275* loss of function - predicted mTORC1 Inhibitor
FBXW7 Q306* loss of function - predicted mTORC1 Inhibitor
FBXW7 Q47* loss of function - predicted mTORC1 Inhibitor
FBXW7 Q631* unknown
FBXW7 R14Q unknown
FBXW7 R179C unknown
FBXW7 R179H unknown
FBXW7 R222* loss of function - predicted mTORC1 Inhibitor
FBXW7 R224* loss of function - predicted mTORC1 Inhibitor
FBXW7 R224Q unknown
FBXW7 R278* loss of function - predicted mTORC1 Inhibitor
FBXW7 R367* loss of function - predicted mTORC1 Inhibitor
FBXW7 R393* loss of function - predicted mTORC1 Inhibitor
FBXW7 R441W unknown
FBXW7 R465C loss of function mTORC1 Inhibitor
FBXW7 R465H loss of function mTORC1 Inhibitor
FBXW7 R465L loss of function mTORC1 Inhibitor
FBXW7 R465P loss of function - predicted mTORC1 Inhibitor
FBXW7 R465Y loss of function - predicted mTORC1 Inhibitor
FBXW7 R473fs loss of function - predicted mTORC1 Inhibitor
FBXW7 R479* loss of function - predicted mTORC1 Inhibitor
FBXW7 R479G loss of function - predicted mTORC1 Inhibitor
FBXW7 R479H loss of function mTORC1 Inhibitor
FBXW7 R479L loss of function mTORC1 Inhibitor
FBXW7 R479P loss of function - predicted mTORC1 Inhibitor
FBXW7 R479Q loss of function mTORC1 Inhibitor
FBXW7 R479S unknown
FBXW7 R505C loss of function mTORC1 Inhibitor
FBXW7 R505G loss of function - predicted
FBXW7 R505H unknown
FBXW7 R505L loss of function mTORC1 Inhibitor
FBXW7 R505S unknown
FBXW7 R543fs unknown
FBXW7 R658* unknown
FBXW7 R658Q unknown
FBXW7 R689Q unknown
FBXW7 R689W unknown
FBXW7 S227A loss of function mTORC1 Inhibitor
FBXW7 S282* loss of function - predicted mTORC1 Inhibitor
FBXW7 S396fs loss of function - predicted
FBXW7 S396N unknown
FBXW7 S398F unknown
FBXW7 S426L unknown
FBXW7 S462Y unknown
FBXW7 S476I unknown
FBXW7 S476R unknown
FBXW7 S516N unknown
FBXW7 S516R unknown
FBXW7 S546L unknown
FBXW7 S558F unknown
FBXW7 S562L unknown
FBXW7 S582L unknown
FBXW7 S601F unknown
FBXW7 S668fs unknown
FBXW7 S86L unknown
FBXW7 T144R unknown
FBXW7 T15_G16insP loss of function mTORC1 Inhibitor
FBXW7 T15_G16insTP unknown
FBXW7 T165fs loss of function - predicted mTORC1 Inhibitor
FBXW7 V154I no effect - predicted
FBXW7 V265I unknown
FBXW7 V418M no effect - predicted
FBXW7 V464E unknown
FBXW7 V464M unknown
FBXW7 V504I unknown
FBXW7 V514F loss of function - predicted
FBXW7 W237* loss of function - predicted mTORC1 Inhibitor
FBXW7 W244* loss of function - predicted mTORC1 Inhibitor
FBXW7 W425C loss of function
FBXW7 W446C unknown
FBXW7 W486* loss of function - predicted mTORC1 Inhibitor
FBXW7 W526L unknown
FBXW7 W526R unknown
FBXW7 W606* unknown
FBXW7 W606* NOTCH1 L1600Q NOTCH1 V1721G NOTCH1 S2467fs
FBXW7 wild-type no effect
FBXW7 Y545C loss of function - predicted