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|Profile Name||FBXW7 del|
|Gene Variant Detail|
|Relevant Treatment Approaches||mTORC1 Inhibitor|
|Molecular Profile||Indication/Tumor Type||Response Type||Relevant Treatment Approaches||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|FBXW7 del||T-cell adult acute lymphocytic leukemia||resistant||MRK-003||Preclinical||Actionable||In a preclinical study, homozygous deletion of FBXW7 is conferred resistance to gamma secretase inhibitor, MRK-003, by activation of the NOTCH pathway and stablization of MYC as demonstrated in T cell acute lymphoblastic leukemia (T-ALL) cell lines (PMID: 17646409).||17646409|