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ID | DOID:5602 |
Name | T-cell adult acute lymphocytic leukemia |
Definition | An adult acute lymphocytic leukemia occurring in adults and that has_material_basis_in T cells. |
Source | DiseaseOntology.org |
Alt Ids | |
Path | disease disease of cellular proliferation cancer organ system cancer hematologic cancer leukemia lymphoid leukemia acute leukemia acute lymphoblastic leukemia adult acute lymphocytic leukemia T-cell adult acute lymphocytic leukemia |
Molecular Profile | Therapy | Indication/Tumor Type | Response Type | Profile Response Detail |
---|---|---|---|---|
FBXW7 R465H | MRK-003 | T-cell adult acute lymphocytic leukemia | resistant | detail... |
FBXW7 del | MRK-003 | T-cell adult acute lymphocytic leukemia | resistant | detail... |
FBXW7 R505C | MRK-003 | T-cell adult acute lymphocytic leukemia | resistant | detail... |
FBXW7 R479Q | MRK-003 | T-cell adult acute lymphocytic leukemia | resistant | detail... |
FBXW7 R465C | MRK-003 | T-cell adult acute lymphocytic leukemia | resistant | detail... |
FBXW7 R505L | MRK-003 | T-cell adult acute lymphocytic leukemia | resistant | detail... |
NOTCH1 mut RB1 wild-type | Ribociclib | T-cell adult acute lymphocytic leukemia | sensitive | detail... |
NOTCH1 wild-type RB1 wild-type | Ribociclib | T-cell adult acute lymphocytic leukemia | sensitive | detail... |
NOTCH1 mut RB1 wild-type | Methotrexate + Ribociclib | T-cell adult acute lymphocytic leukemia | decreased response | detail... |
NOTCH1 wild-type RB1 wild-type | Methotrexate + Ribociclib | T-cell adult acute lymphocytic leukemia | decreased response | detail... |
NOTCH1 mut RB1 wild-type | Mercaptopurine + Ribociclib | T-cell adult acute lymphocytic leukemia | decreased response | detail... |
NOTCH1 wild-type RB1 wild-type | Mercaptopurine + Ribociclib | T-cell adult acute lymphocytic leukemia | decreased response | detail... |
NOTCH1 mut RB1 wild-type | Asparaginase + Ribociclib | T-cell adult acute lymphocytic leukemia | decreased response | detail... |
NOTCH1 wild-type RB1 wild-type | Asparaginase + Ribociclib | T-cell adult acute lymphocytic leukemia | decreased response | detail... |
NOTCH1 mut RB1 wild-type | Dexamethasone + Ribociclib | T-cell adult acute lymphocytic leukemia | sensitive | detail... |
NOTCH1 wild-type RB1 wild-type | Dexamethasone + Ribociclib | T-cell adult acute lymphocytic leukemia | conflicting | detail... |
NOTCH1 wild-type RB1 loss | Ribociclib | T-cell adult acute lymphocytic leukemia | resistant | detail... |
NOTCH1 mut RB1 wild-type | Prednisolone + Ribociclib | T-cell adult acute lymphocytic leukemia | sensitive | detail... |
NOTCH1 wild-type RB1 wild-type | Prednisolone + Ribociclib | T-cell adult acute lymphocytic leukemia | sensitive | detail... |
NOTCH1 mut RB1 wild-type | Everolimus + Ribociclib | T-cell adult acute lymphocytic leukemia | sensitive | detail... |
NOTCH1 wild-type RB1 wild-type | Everolimus + Ribociclib | T-cell adult acute lymphocytic leukemia | sensitive | detail... |
NOTCH1 mut RB1 wild-type | JQ1 + Ribociclib | T-cell adult acute lymphocytic leukemia | sensitive | detail... |
NOTCH1 wild-type RB1 wild-type | JQ1 + Ribociclib | T-cell adult acute lymphocytic leukemia | sensitive | detail... |
NOTCH1 mut RB1 wild-type | Bortezomib + Ribociclib | T-cell adult acute lymphocytic leukemia | sensitive | detail... |
NOTCH1 wild-type RB1 wild-type | Bortezomib + Ribociclib | T-cell adult acute lymphocytic leukemia | sensitive | detail... |
NOTCH1 act mut | Dexamethasone + Ribociclib | T-cell adult acute lymphocytic leukemia | predicted - sensitive | detail... |
Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
---|---|---|---|---|---|---|
NCT01363817 | Phase I | Dexamethasone BMS-906024 | Study to Evaluate the Safety and Tolerability of Weekly Intravenous (IV) Doses of BMS-906024 in Subjects With Acute T-cell Lymphoblastic Leukemia or T-cell Lymphoblastic Lymphoma | Completed | USA | 2 |
NCT02763384 | Phase II | BKT140 + Nelarabine | BL-8040 and Nelarabine for Relapsed or Refractory T-Acute Lymphoblastic Leukemia/ Lymphoblastic Lymphoma | Recruiting | USA | 0 |
NCT02999633 | Phase II | Isatuximab | Safety and Efficacy of Isatuximab in Lymphoblastic Leukemia (ISLAY) | Terminated | USA | 6 |