Disease Detail

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Molecular Profile Therapy Indication/Tumor Type Response Type Profile Response Detail
FBXW7 R465H MRK-003 T-cell adult acute lymphocytic leukemia resistant detail...
FBXW7 del MRK-003 T-cell adult acute lymphocytic leukemia resistant detail...
FBXW7 R505C MRK-003 T-cell adult acute lymphocytic leukemia resistant detail...
FBXW7 R479Q MRK-003 T-cell adult acute lymphocytic leukemia resistant detail...
FBXW7 R465C MRK-003 T-cell adult acute lymphocytic leukemia resistant detail...
FBXW7 R505L MRK-003 T-cell adult acute lymphocytic leukemia resistant detail...
NOTCH1 mut RB1 wild-type Ribociclib T-cell adult acute lymphocytic leukemia sensitive detail...
NOTCH1 wild-type RB1 wild-type Ribociclib T-cell adult acute lymphocytic leukemia sensitive detail...
NOTCH1 mut RB1 wild-type Methotrexate + Ribociclib T-cell adult acute lymphocytic leukemia decreased response detail...
NOTCH1 wild-type RB1 wild-type Methotrexate + Ribociclib T-cell adult acute lymphocytic leukemia decreased response detail...
NOTCH1 mut RB1 wild-type Mercaptopurine + Ribociclib T-cell adult acute lymphocytic leukemia decreased response detail...
NOTCH1 wild-type RB1 wild-type Mercaptopurine + Ribociclib T-cell adult acute lymphocytic leukemia decreased response detail...
NOTCH1 mut RB1 wild-type Asparaginase + Ribociclib T-cell adult acute lymphocytic leukemia decreased response detail...
NOTCH1 wild-type RB1 wild-type Asparaginase + Ribociclib T-cell adult acute lymphocytic leukemia decreased response detail...
NOTCH1 mut RB1 wild-type Dexamethasone + Ribociclib T-cell adult acute lymphocytic leukemia sensitive detail...
NOTCH1 wild-type RB1 wild-type Dexamethasone + Ribociclib T-cell adult acute lymphocytic leukemia conflicting detail...
NOTCH1 wild-type RB1 loss Ribociclib T-cell adult acute lymphocytic leukemia resistant detail...
NOTCH1 mut RB1 wild-type Prednisolone + Ribociclib T-cell adult acute lymphocytic leukemia sensitive detail...
NOTCH1 wild-type RB1 wild-type Prednisolone + Ribociclib T-cell adult acute lymphocytic leukemia sensitive detail...
NOTCH1 mut RB1 wild-type Everolimus + Ribociclib T-cell adult acute lymphocytic leukemia sensitive detail...
NOTCH1 wild-type RB1 wild-type Everolimus + Ribociclib T-cell adult acute lymphocytic leukemia sensitive detail...
NOTCH1 mut RB1 wild-type JQ1 + Ribociclib T-cell adult acute lymphocytic leukemia sensitive detail...
NOTCH1 wild-type RB1 wild-type JQ1 + Ribociclib T-cell adult acute lymphocytic leukemia sensitive detail...
NOTCH1 mut RB1 wild-type Bortezomib + Ribociclib T-cell adult acute lymphocytic leukemia sensitive detail...
NOTCH1 wild-type RB1 wild-type Bortezomib + Ribociclib T-cell adult acute lymphocytic leukemia sensitive detail...
NOTCH1 act mut Dexamethasone + Ribociclib T-cell adult acute lymphocytic leukemia predicted - sensitive detail...
Clinical Trial Phase Therapies Title Recruitment Status
NCT01363817 Phase I Dexamethasone BMS-906024 Study to Evaluate the Safety and Tolerability of Weekly Intravenous (IV) Doses of BMS-906024 in Subjects With Acute T-cell Lymphoblastic Leukemia or T-cell Lymphoblastic Lymphoma Completed
NCT02763384 Phase II BKT140 + Nelarabine BL-8040 and Nelarabine for Relapsed or Refractory T-Acute Lymphoblastic Leukemia/ Lymphoblastic Lymphoma Recruiting
NCT02999633 Phase II Isatuximab Safety and Efficacy of Isatuximab in Lymphoblastic Leukemia (ISLAY) Terminated