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Gene ALK
Variant G1269S
Impact List missense
Protein Effect gain of function - predicted
Gene Variant Descriptions ALK G1269S lies within the protein kinase domain of the Alk protein (UniProt.org). G1269S is predicted to confer a gain of function on the Alk protein as indicated by increased Alk phosphorylation (PMID: 21948233) and has been demonstrated to confer resistance to Alk inhibitors in the context of EML4-ALK (PMID: 21948233, PMID: 22034911).
Associated Drug Resistance Y
Category Variants Paths

ALK mutant ALK act mut ALK G1269S

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Transcript NM_004304.5
gDNA chr2:g.29209815_29209817delGGAinsAGC
cDNA c.3805_3807delGGAinsAGC
Protein p.G1269S
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004304.5 chr2:g.29209815_29209817delGGAinsAGC c.3805_3807delGGAinsAGC p.G1269S RefSeq GRCh38/hg38
NM_004304 chr2:g.29209815_29209817delTCCinsGCT c.3805_3807delGGAinsAGC p.G1269S RefSeq GRCh38/hg38
NM_004304.4 chr2:g.29209815_29209817delGGAinsAGC c.3805_3807delGGAinsAGC p.G1269S RefSeq GRCh38/hg38

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
ALK G1269S Advanced Solid Tumor decreased response TPX-0131 Preclinical - Biochemical Actionable In a preclinical study, ALK G1269S demonstrated reduced sensitivity to TPX-0131 in an in vitro kinase assay (PMID: 34158340). 34158340
ALK G1269S Advanced Solid Tumor predicted - sensitive Conteltinib Preclinical - Biochemical Actionable In a preclinical study, Conteltinib (CT-707) inhibited ALK G1269S activity in an in vitro assay (PMID: 36424628). 36424628