Molecular Profile Detail


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Profile Name ALK G1269S
Gene Variant Detail

ALK G1269S (gain of function - predicted)

Relevant Treatment Approaches ALK Inhibitor


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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
ALK G1269S Advanced Solid Tumor decreased response ALK Inhibitor TPX-0131 Preclinical - Biochemical Actionable In a preclinical study, ALK G1269S demonstrated reduced sensitivity to TPX-0131 in an in vitro kinase assay (PMID: 34158340). 34158340
ALK G1269S Advanced Solid Tumor predicted - sensitive ALK Inhibitor Conteltinib Preclinical - Biochemical Actionable In a preclinical study, Conteltinib (CT-707) inhibited ALK G1269S activity in an in vitro assay (PMID: 36424628). 36424628