Gene Variant Detail

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Gene ALK
Variant G1269A
Impact List missense
Protein Effect unknown
Gene Variant Descriptions ALK G1269A lies within the protein kinase domain of the Alk protein (UniProt.org). G1269A has been demonstrated to occur as a secondary resistance mutation in the context of ALK rearrangement (PMID: 30675302, PMID: 35123209, PMID: 29872693), but has not been biochemically characterized and therefore, its effect on Alk protein function is unknown (PubMed, Nov 2023).
Associated Drug Resistance Y
Category Variants Paths

ALK mutant ALK G1269A

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Transcript NM_004304.5
gDNA chr2:g.29209816C>G
cDNA c.3806G>C
Protein p.G1269A
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004304.4 chr2:g.29209816C>G c.3806G>C p.G1269A RefSeq GRCh38/hg38
NM_004304.5 chr2:g.29209816C>G c.3806G>C p.G1269A RefSeq GRCh38/hg38
NM_004304 chr2:g.29209816C>G c.3806G>C p.G1269A RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
ALK G1269A unknown
EML4 - ALK ALK G1269A Alectinib AZD3463 Brigatinib Ceritinib Lorlatinib
ALK fusion ALK G1269A
EML4 - ALK ALK L1198F ALK G1269A Brigatinib Crizotinib
EML4 - ALK ALK L1196M ALK G1269A
ALK rearrange ALK T1151dup ALK G1269A
EML4 - ALK ALK C1156Y ALK G1269A
EML4 - ALK ALK F1174C ALK G1269A
EML4 - ALK ALK I1171T ALK G1269A
EML4 - ALK ALK I1171N ALK G1269A
ALK rearrange ALK G1202R ALK G1269A
ALK rearrange ALK G1202R ALK L1204V ALK G1269A
ALK rearrange ALK D1203N ALK E1210K ALK G1269A
EML4 - ALK ALK F1174L ALK G1269A
EML4 - ALK ALK F1174L ALK D1203N ALK G1269A
EML4 - ALK ALK T1151M ALK C1156Y ALK F1174L ALK G1202R ALK S1206F ALK G1269A
ALK rearrange ALK G1269A
EML4 - ALK ALK I1171S ALK G1269A
EML4 - ALK ALK G1202R ALK G1269A
EML4 - ALK ALK G1202R ALK L1204V ALK G1269A
EML4 - ALK ALK L1198F ALK G1202R ALK G1269A
EML4 - ALK ALK G1202R ALK S1206F ALK G1269A
ALK fusion ALK G1202R ALK L1204V ALK G1269A
ALK fusion ALK D1203N ALK E1210K ALK G1269A
ALK fusion ALK G1202R ALK S1206F ALK G1269A
EML4 - ALK ALK E1129V ALK I1171T ALK F1174C ALK F1174L ALK F1174V ALK G1269A
EML4 - ALK ALK F1174L ALK E1210K ALK G1269A
EML4 - ALK ALK I1171T ALK F1174L ALK L1196M ALK D1203N ALK E1210K ALK G1269A
ALK L1152V ALK G1269A