Molecular Profile Detail

Profile Name ALK rearrange ALK I1171T
Gene Variant Detail

ALK I1171T (gain of function)

ALK rearrange (unknown)

Relevant Treatment Approaches

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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
ALK rearrange ALK I1171T lung adenocarcinoma resistant Crizotinib Clinical Study Actionable In a clinical case study, a patient with a lung adenocarcinoma tumor harboring an ALK rearrangement and ALK I1171T progressed on Xalkori (crizotinib) therapy after 8 months and resistance was confirmed using cell culture with cells derived from the patient's tumor (PMID: 25228534). 25228534
ALK rearrange ALK I1171T non-small cell lung carcinoma predicted - resistant Brigatinib Clinical Study Actionable In a clinical case study, Alunbrig (brigatinib) treatment resulted in progressive disease in a patient with Alecensa (alectinib)-refractory, ALK-rearranged non-small cell lung cancer with an acquired ALK I1171T (PMID: 29935304). 29935304
ALK rearrange ALK I1171T lung adenocarcinoma resistant Alectinib Clinical Study Actionable In a clinical case study, a patient with a lung adenocarcinoma tumor harboring an ALK rearrangement with ALK I1171T progressed on Alecensa (alectinib) therapy after 4 months and resistance was confirmed using cell culture with cells derived from the patient’s tumor (PMID: 25228534). 25228534
ALK rearrange ALK I1171T non-small cell lung carcinoma predicted - resistant Alectinib Clinical Study Actionable In a clinical case study, ALK I1171T was identified in the post-progression biopsy of a non-small cell lung cancer patients harboring an ALK rearrangement after disease progression on Alecensa (alectinib) treatment (PMID: 29935304). 29935304
Clinical Trial Phase Therapies Title Recruitment Status