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|Profile Name||KIT T670I KIT D816V|
|Gene Variant Detail|
|Relevant Treatment Approaches|
|Molecular Profile||Indication/Tumor Type||Response Type||Relevant Treatment Approaches||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|KIT T670I KIT D816V||Advanced Solid Tumor||decreased response||Midostaurin||Preclinical - Cell culture||Actionable||In a preclinical study, transformed cells co-expressing KIT D816V and KIT T670I demonstrated a decreased response compared to cells expressing KIT D816V alone when treated with Rydapt (midostaurin) in culture (PMID: 31270078).||31270078|
|KIT T670I KIT D816V||Advanced Solid Tumor||resistant||Avapritinib||Preclinical - Cell culture||Actionable||In a preclinical study, transformed cells co-expressing KIT D816V and KIT T670I demonstrated resistance to treatment with Ayvakit (avapritinib) in culture (PMID: 31270078).||31270078|