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|Profile Name||FLT3 exon 14 ins FLT3 D835X NRAS G13C NRAS G13R|
|Gene Variant Detail||
FLT3 exon 14 ins (gain of function - predicted)
NRAS G13C (loss of function - predicted)
|Relevant Treatment Approaches|
|Molecular Profile||Indication/Tumor Type||Response Type||Relevant Treatment Approaches||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|FLT3 exon 14 ins FLT3 D835X NRAS G13C NRAS G13R||acute myeloid leukemia||predicted - resistant||Gilteritinib||Case Reports/Case Series||Actionable||In a clinical study, a patient with acute myeloid leukemia harboring FLT3-ITD and a D835 mutation progressed on Xospata (gilteritinib) treatment and was found to have acquired NRAS G13C and G13R (PMID: 31088841).||31088841|