Molecular Profile Detail

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Profile Name RAD51C T132P
Gene Variant Detail

RAD51C T132P (loss of function)

Relevant Treatment Approaches Olaparib

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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
RAD51C T132P Advanced Solid Tumor sensitive Olaparib Olaparib Preclinical - Cell culture Actionable In a preclinical study, Lynparza (olaparib) treatment resulted in decreased survival of cells expressing RAD51C T132P in culture (PMID: 33832919). 33832919
RAD51C T132P ovarian cancer sensitive Cisplatin + Paclitaxel Case Reports/Case Series Actionable In a clinical case study, treatment with Platinol (cisplatin) plus Taxol (paclitaxel) following surgery resulted in a response with a progression-free survival of at least 10 years in a patient with ovarian cancer harboring RAD51C T132P, and preclinical studies demonstrated cells expressing RAD51C T132P were sensitive to Platinol (cisplatin) in culture (PMID: 33832919). 33832919