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Molecular Profile BRAF V600E
Therapy Binimetinib + Encorafenib
Indication/Tumor Type lung non-small cell carcinoma
Response Type sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
BRAF V600E lung non-small cell carcinoma sensitive Binimetinib + Encorafenib FDA approved - On Companion Diagnostic Actionable In a Phase II trial (PHAROS) that supported FDA approval, Braftovi (encorafenib) and Mektovi (binimetinib) combination therapy resulted in an objective response rate (ORR) of 75% (44/59; 9 complete, 35 partial responses) with a duration of response (DOR) lasting 12 or more months in 59% of treatment-naive patients, and an ORR of 46% (18/39) with a DOR lasting 12 or more months in 33% of previously treated patients with metastatic non-small cell lung cancer harboring BRAF V600E (PMID: 37270692; NCT03915951). detail... detail... detail... 37270692
BRAF V600E lung non-small cell carcinoma sensitive Binimetinib + Encorafenib Guideline Actionable Combination of Braftovi (encorafenib) and Mektovi (binimetinib) is included in guidelines as a first-line or subsequent therapy for advanced or metastatic non-small cell lung cancer patients harboring BRAF V600E mutations (NCCN.org). detail...
PubMed Id Reference Title Details
FDA.gov Full reference...
NCCN.org Full reference...
Full reference...
Braftovi (encorafenib) FDA Drug Label Full reference...
(37270692) Phase II, Open-Label Study of Encorafenib Plus Binimetinib in Patients With BRAFV600-Mutant Metastatic Non-Small-Cell Lung Cancer. Full reference...