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Molecular Profile IDH1 mutant
Therapy N/A
Indication/Tumor Type malignant glioma
Response Type not applicable

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
IDH1 mutant malignant glioma not applicable N/A Guideline Prognostic IDH1 mutations are associated with a favorable prognosis in patients with glioma, and are associated with a survival benefit for patients treated with radiation or alkylator therapy (NCCN.org). detail...
IDH1 mutant malignant glioma not applicable N/A Clinical Study Prognostic In multiple clinical studies, including two meta-analyses, IDH1 mutations were associated with improved overall survival and progression free survival in patients with gliomas (PMID: 23817809, PMID: 26220714, PMID: 23894344). 23894344 23817809 26220714
IDH1 mutant malignant glioma not applicable N/A Guideline Diagnostic IDH1 mutations aid in the diagnosis of gliomas (PMID: 23041832, PMID: 19755387, PMID: 19915484; NCCN.org). detail... 23041832 19755387 19915484
PubMed Id Reference Title Details
(23817809) A population-based study of low-grade gliomas and mutated isocitrate dehydrogenase 1 (IDH1). Full reference...
(26220714) Prognostic role of IDH mutations in gliomas: a meta-analysis of 55 observational studies. Full reference...
(23894344) IDH1/IDH2 mutations define the prognosis and molecular profiles of patients with gliomas: a meta-analysis. Full reference...
(23041832) Diagnostic implications of IDH1-R132H and OLIG2 expression patterns in rare and challenging glioblastoma variants. Full reference...
(19755387) IDH1 mutations as molecular signature and predictive factor of secondary glioblastomas. Full reference...
(19915484) Diagnostic use of IDH1/2 mutation analysis in routine clinical testing of formalin-fixed, paraffin-embedded glioma tissues. Full reference...
NCCN.org Full reference...
NCCN.org Full reference...