Profile Response Detail

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Molecular Profile IDH1 mutant
Therapy N/A
Indication/Tumor Type glioblastoma
Response Type not applicable

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
IDH1 mutant glioblastoma not applicable N/A Guideline Diagnostic IDH1 mutations aid in the diagnosis of secondary grade IV glioblastomas (NCCN.org). detail...
IDH1 mutant glioblastoma not applicable N/A Clinical Study Prognostic In multiple clinical studies, including two meta-analyses, IDH1 mutations were associated with a greater overall survival and progression-free survival in patients with glioblastoma (PMID: 23904262, PMID: 26945349, PMID: 20560678). 20560678 23904262 26945349
PubMed Id Reference Title Details
(23904262) IDH1 mutation is associated with improved overall survival in patients with glioblastoma: a meta-analysis. Full reference...
(26945349) Isocitrate Dehydrogenase (IDH)1/2 Mutations as Prognostic Markers in Patients With Glioblastomas. Full reference...
(20560678) Prognostic value of IDH1 mutations identified with PCR-RFLP assay in glioblastoma patients. Full reference...
NCCN.org Full reference...