Reference Detail


Missing content? – Request curation!

Request curation for specific Genes, variants, or PubMed publications.

Have questions, comments or suggestions? - Let us know!

Email us at :

Ref Type
Authors Abdul Rafeh Naqash, Arjun Mittra, Geraldine Helen O'Sullivan Coyne, Li Chen, Biswajit Das, Shivaani Kummar, Khanh T Do, Ting-Chia Chang, Ashley Bruns, Lamin Juwara, Brandon Miller, Robert J. Kinders, Ralph E. Parchment, Larry V Rubinstein, Jiuping Jay Ji, Deborah Wilsker, Angie B Dull, James H. Doroshow, Alice P. Chen, Naoko Takebe
Title Tumor genomic analysis for biomarker identification in a phase I trial of the Wee 1 inhibitor adavosertib (AZD1775).
Abstract Text J Clin Oncol 38: 2020 (suppl; abstr 3624)


  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"


  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown Advanced Solid Tumor not applicable Adavosertib Phase I Actionable In a Phase I trial, Adavosertib (MK-1775) treatment resulted in a partial response in 17% (6/35) and stable disease in 51.4% (18/35) of patients with advanced solid tumors, with a median duration of response of 5.2 months (J Clin Oncol 38: 2020 (suppl; abstr 3624); NCT01748825). detail...