TET2
|
D545Tfs*10
|
frameshift |
loss of function - predicted |
TET2 D545Tfs*10 indicates a shift in the reading frame starting at amino acid 545 and terminating 10 residues downstream causing a premature truncation of the 2002 amino acid Tet2 protein (UniProt.org). D545Tfs*10 has not been characterized however, due to the effects of other truncation mutations downstream of D545Tfs*10 (PMID: 24994606), is predicted to lead to a loss of Tet2 protein function. |
|
TET2
|
E1323*
|
nonsense |
loss of function - predicted |
TET2 E1323* results in a premature truncation of the Tet2 protein at amino acid 1323 of 2002 (UniProt.org). E1323* has not been characterized however, due to the effects of other truncation mutations downstream of E1323* (PMID: 24994606), is predicted to lead to a loss of Tet2 protein function. |
|
TET2
|
E320*
|
nonsense |
loss of function - predicted |
TET2 E320* results in a premature truncation of the Tet2 protein at amino acid 320 of 2002 (UniProt.org). E320* has not been characterized however, due to the effects of other truncation mutations downstream of E320* (PMID: 24994606), is predicted to lead to a loss of Tet2 protein function. |
|
TET2
|
I249fs
|
frameshift |
loss of function - predicted |
TET2 I249fs results in a change in the amino acid sequence of the Tet2 protein beginning at aa 249 of 2002, likely resulting in premature truncation of the functional protein (UniProt.org). I249fs has not been characterized, however, due to the effects of other truncation mutations downstream of I249 (PMID: 24994606), is predicted to lead to a loss of Tet2 protein function. |
|
TET2
|
K450*
|
nonsense |
loss of function - predicted |
TET2 K450* results in a premature truncation of the Tet2 protein at amino acid 450 of 2002 (UniProt.org). K450* has not been characterized however, due to the effects of other truncation mutations downstream of K450* (PMID: 24994606), is predicted to lead to a loss of Tet2 protein function. |
|
TET2
|
Q1191*
|
nonsense |
loss of function - predicted |
TET2 Q1191* results in a premature truncation of the Tet2 protein at amino acid 1191 of 2002 (UniProt.org). Q1191* has not been characterized however, due to the effects of other truncation mutations downstream of Q1191* (PMID: 24994606), is predicted to lead to a loss of Tet2 protein function. |
|
TET2
|
Q1414*
|
nonsense |
loss of function - predicted |
TET2 Q1414* results in a premature truncation of the Tet2 protein at amino acid 1414 of 2002 (UniProt.org). Q1414* has not been characterized however, due to the effects of other truncation mutations downstream of Q1414* (PMID: 24994606), is predicted to lead to a loss of Tet2 protein function. |
|
TET2
|
Q591*
|
nonsense |
loss of function - predicted |
TET2 Q591* results in a premature truncation of the Tet2 protein at amino acid 591 of 2002 (UniProt.org). Q591* has not been characterized however, due to the effects of other truncation mutations downstream of Q591* (PMID: 24994606), is predicted to lead to a loss of Tet2 protein function. |
|
TET2
|
Q642*
|
nonsense |
loss of function - predicted |
TET2 Q642* results in a premature truncation of the Tet2 protein at amino acid 642 of 2002 (UniProt.org). Q642* has not been characterized however, due to the effects of other truncation mutations downstream of Q642* (PMID: 24994606), is predicted to lead to a loss of Tet2 protein function. |
|
TET2
|
Q652*
|
nonsense |
loss of function - predicted |
TET2 Q652* results in a premature truncation of the Tet2 protein at amino acid 652 of 2002 (UniProt.org). Q652* has not been characterized however, due to the effects of other truncation mutations downstream of Q652* (PMID: 24994606), is predicted to lead to a loss of Tet2 protein function. |
|
TET2
|
Q690*
|
nonsense |
loss of function - predicted |
TET2 Q690* results in a premature truncation of the Tet2 protein at amino acid 690 of 2002 (UniProt.org). Q690* has not been characterized however, due to the effects of other truncation mutations downstream of Q690* (PMID: 24994606), is predicted to lead to a loss of Tet2 protein function. |
|
TET2
|
Q701*
|
nonsense |
loss of function - predicted |
TET2 Q701* results in a premature truncation of the Tet2 protein at amino acid 701 of 2002 (UniProt.org). Q701* has not been characterized, however, due to the effects of other truncation mutations downstream of Q701 (PMID: 24994606), is predicted to lead to a loss of Tet2 protein function. |
|
TET2
|
Q891fs
|
frameshift |
loss of function - predicted |
TET2 Q891fs results in a change in the amino acid sequence of the Tet2 protein beginning at aa 891 of 2002, likely resulting in premature truncation of the functional protein (UniProt.org). Q891fs has not been characterized, however, due to the effects of other truncation mutations downstream of Q891 (PMID: 24994606), is predicted to lead to a loss of Tet2 protein function. |
|
TET2
|
Q916*
|
nonsense |
loss of function - predicted |
TET2 Q916* results in a premature truncation of the Tet2 protein at amino acid 916 of 2002 (UniProt.org). Q916* has not been characterized however, due to the effects of other truncation mutations downstream of Q916* (PMID: 24994606), is predicted to lead to a loss of Tet2 protein function. |
|
TET2
|
Q958Rfs*49
|
frameshift |
loss of function - predicted |
TET2 Q958Rfs*49 indicates a shift in the reading frame starting at amino acid 958 and terminating 49 residues downstream causing a premature truncation of the 2002 amino acid Tet2 protein (UniProt.org). Q958Rfs*49 has not been characterized, however, due to the effects of other truncation mutations downstream of Q958 (PMID: 24994606), is predicted to lead to a loss of Tet2 protein function. |
|
TET2
|
R1067*
|
nonsense |
loss of function - predicted |
TET2 R1067* results in a premature truncation of the Tet2 protein at amino acid 1067 of 2002 (UniProt.org). R1067* has not been characterized however, due to the effects of other truncation mutations downstream of $1067* (PMID: 24994606), is predicted to lead to a loss of Tet2 protein function. |
|
TET2
|
R1179Efs*47
|
frameshift |
loss of function - predicted |
TET2 R1179Efs*47 indicates a shift in the reading frame starting at amino acid 1179 and terminating 47 residues downstream causing a premature truncation of the 2002 amino acid Tet2 protein (UniProt.org). R1179Efs*47 has not been characterized, however, due to the effects of other truncation mutations downstream of R1179 (PMID: 24994606), is predicted to lead to a loss of Tet2 protein function. |
|
TET2
|
R1404*
|
nonsense |
loss of function - predicted |
TET2 R1404* results in a premature truncation of the Tet2 protein at amino acid 1404 of 2002 (UniProt.org). R1404* has not been characterized however, due to the effects of other truncation mutations downstream of R1404* (PMID: 24994606), is predicted to lead to a loss of Tet2 protein function. |
|
TET2
|
R1465*
|
nonsense |
loss of function - predicted |
TET2 R1465* results in a premature truncation of the Tet2 protein at amino acid 1465 of 2002 (UniProt.org). R1465* has not been characterized, however, due to the effects of other truncation mutations downstream of R1465 (PMID: 24994606), is predicted to lead to a loss of Tet2 protein function. |
|
TET2
|
R506*
|
nonsense |
loss of function - predicted |
TET2 R506* results in a premature truncation of the Tet2 protein at amino acid 506 of 2002 (UniProt.org). R506* results in a loss of -5-hydroxymethylcytosine (5hmc) formation in cultured cells (PMID: 24994606), and therefore, is predicted to lead to a loss of Tet2 protein function. |
|
TET2
|
S1758*
|
nonsense |
loss of function - predicted |
TET2 S1758* results in a premature truncation of the Tet2 protein at amino acid 1758 of 2002 (UniProt.org). S1758* results in a loss of -5-hydroxymethylcytosine (5hmc) formation in cultured cells (PMID: 24994606), and therefore, is predicted to lead to a loss of Tet2 protein function. |
|
TET2
|
S354*
|
nonsense |
loss of function - predicted |
TET2 S354* results in a premature truncation of the Tet2 protein at amino acid 354 of 2002 (UniProt.org). S354* has not been characterized, however, due to the effects of other truncation mutations downstream of S354 (PMID: 24994606), is predicted to lead to a loss of Tet2 protein function. |
|
TET2
|
S792*
|
nonsense |
loss of function - predicted |
TET2 S792* results in a premature truncation of the Tet2 protein at amino acid 792 of 2002 (UniProt.org). S792* has not been characterized however, due to the effects of other truncation mutations downstream of S792* (PMID: 24994606), is predicted to lead to a loss of Tet2 protein function. |
|
TET2
|
S833Ffs*8
|
frameshift |
loss of function - predicted |
TET2 S833Ffs*8 indicates a shift in the reading frame starting at amino acid 833 and terminating 8 residues downstream causing a premature truncation of the 2002 amino acid Tet2 protein (UniProt.org). S833Ffs*8 has not been characterized, however, due to the effects of other truncation mutations downstream of S833 (PMID: 24994606), is predicted to lead to a loss of Tet2 protein function. |
|
TET2
|
S835*
|
nonsense |
loss of function - predicted |
TET2 S835* results in a premature truncation of the Tet2 protein at amino acid 835 of 2002 (UniProt.org). S835* has not been characterized, however, due to the effects of other truncation mutations downstream of S835 (PMID: 24994606), is predicted to lead to a loss of Tet2 protein function. |
|
TET2
|
T1063Nfs*5
|
frameshift |
loss of function - predicted |
TET2 T1063Nfs*5 indicates a shift in the reading frame starting at amino acid 1063 and terminating 5 residues downstream causing a premature truncation of the 2002 amino acid Tet2 protein (UniProt.org). T1063Nfs*5 has not been characterized, however, due to the effects of other truncation mutations downstream of T1063 (PMID: 24994606), is predicted to lead to a loss of Tet2 protein function. |
|
TET2
|
V1006Gfs*3
|
frameshift |
loss of function - predicted |
TET2 V1006Gfs*3 indicates a shift in the reading frame starting at amino acid 1006 and terminating 3 residues downstream causing a premature truncation of the 2002 amino acid Tet2 protein (UniProt.org). V1006Gfs*3 has not been characterized, however, due to the effects of other truncation mutations downstream of V1006 (PMID: 24994606), is predicted to lead to a loss of Tet2 protein function. |
|
TET2
|
W1198*
|
nonsense |
loss of function - predicted |
TET2 W1198* results in a premature truncation of the Tet2 protein at amino acid 1198 of 2002 (UniProt.org). W1198* has not been characterized however, due to the effects of other truncation mutations downstream of W1198* (PMID: 24994606), is predicted to lead to a loss of Tet2 protein function. |
|