Therapy Detail

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Therapy Name Cisplatin + Xevinapant
Synonyms
Therapy Description

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Cisplatin Platinol CDDP Chemotherapy - Platinum 7 Platinol (cisplatin) is a platinum based chemotherapeutic, which is FDA approved for bladder, ovarian, and testicular cancers (NCI Drug Dictionary).
Xevinapant AT-406|SM-406|Debio1143|Debio-1143|Debio 1143 SMAC Mimetic 8 Xevinapant (debio 1143) is a SMAC mimetic, which antagonizes Inhibitor of Apoptosis Protein (IAP) family proteins, resulting in increased tumor cell apoptosis, decreased tumor growth (PMID: 21443232), and may reverse immunosuppression (PMID: 30352911, PMID: 32758455).

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT06145412 Phase II Cisplatin + Xevinapant A Study of Xevinapant With Cisplatin and Radiation Therapy After Surgery in People With Head and Neck Cancer Recruiting USA 0
NCT06056310 Phase I Cisplatin + Xevinapant Xevinapant Phase 1b Safety Study of Xevinapant, Weekly Cisplatin, and RT in Participants With Unresected LA SCCHN (HyperlynX) Recruiting USA | ESP | BEL 3
NCT04459715 Phase III Cisplatin + Xevinapant Cisplatin A Study of Xevinapant (Debio 1143) in Combination With Platinum-Based Chemotherapy and Standard Fractionation Intensity-Modulated Radiotherapy in Participants With Locally Advanced Squamous Cell Carcinoma of the Head and Neck, Suitable for Definitive Chemoradiotherapy (TrilynX) Active, not recruiting USA | ITA | GBR | FRA | ESP | DEU | CAN | BEL | AUT | AUS 16


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