Therapy Detail

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Therapy Name RP-3500
Synonyms
Therapy Description

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Drug Name Trade Name Synonyms Drug Classes Drug Description
RP-3500 RP 3500|RP3500 ATR Inhibitor 14 RP-3500 binds to and inhibits ATR, resulting in inhibition of downstream signaling and impaired DNA damage repair, potentially leading to induction of apoptosis in tumor cells (NCI Drug Dictionary).

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
ATM inact mut Advanced Solid Tumor predicted - sensitive RP-3500 Phase Ib/II Actionable In a Phase I/II trial (TRESR), RP-3500 treatment resulted in a response rate of 13% (13/98), clinical benefit rate (CBR) of 47% (36/77), and median progression-free survival (mPFS) of 15 weeks in solid tumor patients with inactivating mutations in DNA damage repair genes, including ATM, with a CBR of >60% and mPFS not reached in 17 ovarian tumor patients, and with biallelic ATM inactivation CBR was 64% (7/11) vs 0% (0/3) with monoallelic inactivation (Cancer Res 2022;82(12_Suppl): CT030, NCT04497116). detail...
RAD51C inact mut Advanced Solid Tumor predicted - sensitive RP-3500 Phase Ib/II Actionable In a Phase I/II trial (TRESR), RP-3500 treatment resulted in a response rate of 13% (13/98), clinical benefit rate (CBR) of 47% (36/77), and median progression-free survival (mPFS) of 15 weeks in solid tumor patients with inactivating mutations in DNA damage repair genes, including RAD51C, with a CBR of >60% and mPFS not reached in 17 ovarian tumor patients (Cancer Res 2022;82(12_Suppl): CT030, NCT04497116). detail...

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT05566574 Phase Ib/II RP-3500 A Study of RP-3500 in Combination With Standard Radiation Therapy in People With Solid Tumor Cancer Recruiting USA 0
NCT04497116 Phase Ib/II RP-3500 + Talazoparib RP-3500 Study of RP-3500 in Advanced Solid Tumors Recruiting USA | CAN 2


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