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|Therapy Name||CPI-0610 + Rucaparib|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|CPI-0610||CPI0610||BET Inhibitor (Pan) 30||CPI-0610 is a small molecule that binds to BET bromodomains and inhibits interaction with acetylated histones, resulting in regulation of BET-dependent gene expression and anti-tumor effects (PMID: 26815195, PMID: 31729905).|
|Rucaparib||Rubraca||AG014699|PF-01367338|CO-388|AG14447||PARP Inhibitor (Pan) 22||Rubraca (rucaparib) binds to and inhibits PARP, which may result in accumulation of DNA damage and chemosensitization of tumor cells (PMID: 17363489). Rubraca (rucaparib) is FDA approved for use as a maintenance therapy in patients with platinum-sensitive recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer, for treatment in patients with epithelial ovarian, fallopian tube, or primary peritoneal cancer harboring deleterious somatic and/or germline BRCA mutations who received 2 or more chemotherapies, and in patients with a deleterious BRCA mutation (germline and/or somatic)-associated metastatic castration-resistant prostate cancer who received anti-androgen therapy and a taxane-based therapy (FDA.gov).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Unknown unknown||ovarian cancer||not applicable||CPI-0610 + Rucaparib||Preclinical - Cell line xenograft||Actionable||In a preclinical study, the combination treatment of Rubraca (rucaparib) and CPI-0610 resulted in a synergistic effect, demonstrating greater inhibition of cell growth and colony formation in cultured ovarian cancer cells and a 58% decrease in tumor weight in cell line xenograft models (PMID: 32927276).||32927276|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|