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|Therapy Name||Talquetamab + Teclistamab|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|Talquetamab||JNJ64407564|JNJ 64407564|JNJ-64407564||CD3 Antibody 78||Talquetamab (JNJ-64407564) is a bispecific antibody that targets CD3 and GPRC5D, potentially resulting in increased immune response against GPRC5D-expressing tumor cells (PMID: 32040549).|
|Teclistamab||Tecvayli||JNJ-64007957|BCMAxCD3|JNJ 64007957|JNJ64007957||CD3 Antibody 78 TNFRSF17 Antibody 14||Tecvayli (teclistamab) is a bispecific antibody that targets CD3 and BCMA, potentially resulting in increased immune response against BCMA-expressing tumor cells (Blood Dec 2016, 128 (22) 5668). Tecvayli (teclistamab) is FDA approved for use in adult patients with relapsed or refractory multiple myeloma who have received four or more prior lines of therapy (FDA.gov).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|
|NCT04586426||Phase I||Talquetamab + Teclistamab||A Study of the Combination of Talquetamab and Teclistamab in Participants With Relapsed or Refractory Multiple Myeloma||Recruiting||ESP | CAN||2|