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|Therapy Name||Carboplatin + CC-90011 + Etoposide|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|CC-90011||CC90011|CC 90011||KDM1A Inhibitor 12||CC-90011 is an inhibitor of KDM1A (LSD1), which potentially increases H3K4 methylation leading to growth inhibition of LSD1-overexpressing cancer cells (PMID: 31801559).|
|Carboplatin||Paraplatin||CBDCA||Chemotherapy - Platinum 7||Paraplatin (carboplatin) is a second-generation platinum compound and is activated intracellularly to form reactive platinum complexes that cross link DNA with DNA and with proteins. This induces apoptosis and inhibits cell growth (NCI Drug Dictionary).|
|Etoposide||Vepesid||EPEG|Eposin|VP-16|VP-16-213||TOPO2 inhibitor 5||Vepesid (etoposide) binds to and inhibits DNA topoisomerase II, resulting in accumulated DNA damage, inhibition of replication, and cell death (NCI Drug Dictionary).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|
|NCT03850067||Phase Ib/II||Carboplatin + CC-90011 + Etoposide CC-90011 + Cisplatin + Etoposide Nivolumab||A Safety, Tolerability and Preliminary Efficacy Evaluation of CC-90011 Given in Combination With Cisplatin and Etoposide in Subjects With First Line, Extensive Stage Small Cell Lung Cancer||Recruiting||3|