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|Therapy Name||AZD0156 + GSK690693|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|AZD0156||AZD-0156||ATM Inhibitor 11||AZD0156 is an inhibitor of ataxia telangiectasia mutated (ATM) kinase and radiosensitizer, which leads to defective DNA damage repair and apoptosis in tumor cells (PMID: 31534013).|
|GSK690693||GSK-690693||AKT Inhibitor (Pan) - ATP competitive 7||GSK690693 is a ATP-competitive pan-AKT inhibitor, which inhibits AKT signaling, resulting in decreased proliferation and increased apoptosis of tumor cells (PMID: 18381444, PMID: 31377021).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|PIK3CA E545K||breast cancer||sensitive||AZD0156 + GSK690693||Preclinical - Cell culture||Actionable||In a preclinical study, AZD0156 and GSK690693 combination treatment increased cell death compared to GSK690693 alone in a breast cancer cell line harboring PIK3CA E545K in culture (PMID: 32439931).||32439931|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|