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|Therapy Name||Bevacizumab + Carboplatin + GL-ONC1|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|Bevacizumab||Avastin||VEGF Antibody 10 VEGFR Inhibitor (Pan) 33||Avastin (bevacizumab) is a monoclonal antibody that binds VEGF and inhibits binding to VEGFR, potentially resulting in decreased tumor growth (PMID: 15136787). Avastin (bevacizumab) is FDA approved for use in colorectal cancer, non-small cell lung cancer, glioblastoma, renal cell carcinoma, cervical carcinoma, and ovarian cancer, and in combination with carboplatin and paclitaxel in epithelial ovarian, fallopian tube, or primary peritoneal cancer (FDA.gov).|
|Carboplatin||Paraplatin||CBDCA||Chemotherapy - Platinum 7||Paraplatin (carboplatin) is a second-generation platinum compound and is activated intracellularly to form reactive platinum complexes that cross link DNA with DNA and with proteins. This induces apoptosis and inhibits cell growth (NCI Drug Dictionary).|
|GL-ONC1||GLV-1h68|Olvimulogene nanivacirepvec|Olvi-Vec||Olvimulogene nanivacirepvec (GL-ONC1) is a genetically engineered light-emitting oncolytic vaccinia virus, which results in viral infection within the cells, thereby possibly inducing cell death and interruption of the cell cycle (PMID: 28679776, PMID: 31567308).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|
|NCT05281471||Phase III||Bevacizumab + Carboplatin Bevacizumab + Cisplatin Bevacizumab + Carboplatin + GL-ONC1 Bevacizumab + Cisplatin + GL-ONC1||Efficacy & Safety of Olvi-Vec and Platinum-doublet + Bevacizumab Compared to Platinum-doublet + Bevacizumab in Platinum-Resistant/Refractory Ovarian Cancer (OnPrime)||Recruiting||USA||0|