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|Therapy Name||Carboplatin + DNIB0600A|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|Carboplatin||Paraplatin||CBDCA||Chemotherapy - Platinum 6||Paraplatin (carboplatin) is a second-generation platinum compound and is activated intracellularly to form reactive platinum complexes that cross link DNA with DNA and with proteins. This induces apoptosis and inhibits cell growth (NCI Drug Dictionary).|
|DNIB0600A||Lifastuzumab vedotin|RG-7599||DNIB0600A (Lifastuzumab vedotin) is an antibody-drug conjugate consists of an antibody targeting SLC34A2 and monomethyl auristatin E, which may lead to disruption of the microtubule network in SLC34A2-expressing cancer cells, thereby potentially inhibiting cell proliferation (PMID: 29401246, PMID: 32534811, PMID: 31540980).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Unknown unknown||ovarian cancer||not applicable||Carboplatin + DNIB0600A||Phase I||Actionable||In a Phase Ib trial, the combination of DNIB0600A (Lifastuzumab vedotin) and Paraplatin (carboplatin) with or without Avastin (bevacizumab) demonstrated safety in patients with recurrent ovarian cancer and resulted in an objective response rate (ORR) of 59% (24/41), with a median progression-free survival (PFS) of 10.7 months, DNIB0600A (Lifastuzumab vedotin) at RP2D (2.4 mg/kg) with Paraplatin (carboplatin) resulted in an ORR of 50% (10/20) and a median PFS of 8.5 months (PMID: 32534811; NCT01995188).||32534811|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|
|NCT01995188||Phase I||Bevacizumab + Carboplatin + DNIB0600A Carboplatin + DNIB0600A||A Study to Evaluate the Safety and Pharmacology of DNIB0600A in Patients With Ovarian Cancer||Completed||USA||0|