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Fostamatinib (R788) binds and inhibits Syk kinase thus interfering with mast cell, macrophage, and B-cell activation as well as downstream events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis (NCI drug dictionary)
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|Fostamatinib||Tavalisse||R788|R935788||SYK Inhibitor 14||Fostamatinib (R788) binds and inhibits Syk kinase thus interfering with mast cell, macrophage, and B-cell activation as well as downstream events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis (NCI Drug Dictionary).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|RB1 inact mut||retinoblastoma||sensitive||Fostamatinib||Preclinical||Actionable||In a preclinical study, retinoblastoma cell lines demonstrated sensitivity to Fostamatinib resulting in cell death (PMID: 22237022).||22237022|
|Unknown unknown||diffuse large B-cell lymphoma||no benefit||Fostamatinib||Phase II||Actionable||In a Phase II clinical trial, fostamatinib demonstrated safety, but limited efficacy in patients with diffuse large B-cell lymphoma, with an objective response rate of 3% (2/68) and stable disease in 10% (7/68) of patients (PMID: 26707592).||26707592|
|Unknown unknown||lung carcinoma||not applicable||Fostamatinib||Preclinical - Cell culture||Actionable||In a preclinical study, Fostamatinib (R788) treatment induced cytotoxicity in Lewis lung carcinoma cells in culture and inhibited tumor growth in a syngeneic mouse model (PMID: 31974273).||31974273|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|
|NCT02611063||Phase I||Fostamatinib||Evaluation of Fostamatinib in Patients With cGVHD After Allogeneic Stem Cell Transplant||Recruiting||USA||0|