Therapy Detail

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Therapy Name SAR405838
Synonyms
Therapy Description

SAR405838 (MI-77301) binds to MDM2 and inhibits MDM2-p53 interaction, resulting in activation of wild-type p53 signaling and decreased tumor growth (PMID: 25145672, PMID: 30585255, PMID: 31619389).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
SAR405838 MI-77301|MI-773|MI773|SAR-405838 MDM2 Inhibitor 22 SAR405838 (MI-77301) binds to MDM2 and inhibits MDM2-p53 interaction, resulting in activation of wild-type p53 signaling and decreased tumor growth (PMID: 25145672, PMID: 30585255, PMID: 31619389).

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
TP53 wild-type prostate cancer sensitive SAR405838 Preclinical - Cell line xenograft Actionable In a preclinical study, SAR405838 inhibited growth of TP53 wild-type prostate cancer cells in culture and resulted in tumor regression in cell line xenograft models (PMID: 25145672). 25145672
TP53 wild-type colon cancer sensitive SAR405838 Preclinical - Cell line xenograft Actionable In a preclinical study, SAR405838 inhibited growth of TP53 wild-type colon cancer cells in culture and resulted in tumor regression in cell line xenograft models (PMID: 25145672). 25145672
TP53 wild-type acute leukemia sensitive SAR405838 Preclinical - Cell line xenograft Actionable In a preclinical study, SAR405838 inhibited growth of TP53 wild-type acute leukemia cells in culture and resulted in tumor regression in cell line xenograft models (PMID: 25145672). 25145672
TP53 wild-type breast cancer predicted - sensitive SAR405838 Preclinical - Pdx Actionable In a preclinical study, SAR405838 (MI-77301) induced p53 signaling and inhibited tumor growth in patient-derived xenograft models of endocrine therapy-resistant breast cancer with wild-type TP53, and induced cell-cycle arrest and inhibited growth of patient-derived endocrine therapy-resistant breast cancer cells in culture (PMID: 27765850). 27765850
TP53 wild-type salivary gland adenoid cystic carcinoma predicted - sensitive SAR405838 Preclinical - Pdx Actionable In a preclinical study, treatment with SAR405838 (MI-773) resulted in activation of Mdm2 and Tp53 in patient-derived salivary gland adenoid cystic carcinoma (ACC) cells in culture, and led to induction of apoptosis and tumor regression in ACC patient-derived xenograft (PDX) models with wild-type TP53 (PMID: 26936915). 26936915

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT01636479 Phase I SAR405838 Phase 1 Safety Testing of SAR405838 Completed USA | NLD | FRA 0


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