Therapy Detail

Therapy Name TAE226
Synonyms
Therapy Description

TAE226 inhibits FAK and IGF-IR, resulting in decreased signaling pathway activation, decreased tumor cell growth and invasion, and increased cell-cycle arrest (PMID: 17431114).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
TAE226 FAK inhibitor 14 IGF-1R Inhibitor 17 TAE226 inhibits FAK and IGF-IR, resulting in decreased signaling pathway activation, decreased tumor cell growth and invasion, and increased cell-cycle arrest (PMID: 17431114).

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

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  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
BRAF G469A lung non-small cell carcinoma sensitive TAE226 Preclinical Actionable In a preclinical study, TAE226 treatment inhibited proliferation of non-small cell lung carcinoma cell lines harboring BRAF G469A mutation in culture (PMID: 26090892). 26090892
EGFR L858R Advanced Solid Tumor sensitive TAE226 Preclinical Actionable In a preclinical study, TAE226 treatment inhibited proliferation of transformed human cell lines harboring EGFR L858R mutation in culture (PMID: 26090892). 26090892
Unknown unknown oral squamous cell carcinoma not applicable TAE226 Preclinical - Cell line xenograft Actionable In a preclinical study, TAE226 treatment increased apoptosis and decreased proliferation and migration of oral squamous cell carcinoma cells in culture and inhibited tumor growth in cell line xenograft models (PMID: 22766511). 22766511
EGFR L858R EGFR T790M lung non-small cell carcinoma sensitive TAE226 Preclinical Actionable In a preclinical study, TAE226 treatment inhibited proliferation of non-small cell lung carcinoma cell lines harboring both EGFR L858R and EGFR T790M mutations in culture (PMID: 26090892). 26090892
EML4-ALK lung non-small cell carcinoma sensitive TAE226 Preclinical Actionable In a preclinical study, TAE226 treatment inhibited proliferation of non-small cell lung carcinoma cell lines harboring EML4-ALK fusion in culture (PMID: 26090892). 26090892
EGFR exon 19 del lung non-small cell carcinoma sensitive TAE226 Preclinical - Cell line xenograft Actionable In a preclinical study, TAE226 treatment inhibited cell proliferation and decreased xenograft tumor size of non-small cell lung carcinoma cell lines harboring EGFR Exon 19 deletion mutation (PMID: 26090892). 26090892
MET amp stomach cancer sensitive TAE226 Preclinical Actionable In a preclinical study, TAE226 treatment inhibited proliferation of gastric cancer cell lines harboring MET amplification in culture (PMID: 26090892). 26090892
EGFR L858R lung non-small cell carcinoma sensitive TAE226 Preclinical Actionable In a preclinical study, TAE226 treatment inhibited proliferation of non-small cell lung carcinoma cell lines harboring EGFR L858R mutation in culture (PMID: 26090892). 26090892
BRAF G466V lung non-small cell carcinoma sensitive TAE226 Preclinical Actionable In a preclinical study, TAE226 treatment inhibited proliferation of non-small cell lung carcinoma cell lines harboring BRAF G466V mutation in culture (PMID: 26090892). 26090892
EGFR wild-type lung non-small cell carcinoma decreased response TAE226 Preclinical Actionable In a preclinical study, TAE226 treatment demonstrated reduced potency inhibiting proliferation of non-small cell lung carcinoma cell lines harboring wild-type EGFR in culture (PMID: 26090892). 26090892
EGFR exon 19 del EGFR T790M lung non-small cell carcinoma sensitive TAE226 Preclinical - Cell line xenograft Actionable In a preclinical study, TAE226 treatment inhibited proliferation of non-small cell lung cancer cell lines harboring both EGFR T790M and EGFR exon 19 deletion mutations, and decreased tumor size in xenograft models (PMID: 26090892). 26090892
MET amp lung non-small cell carcinoma sensitive TAE226 Preclinical Actionable In a preclinical study, TAE226 treatment inhibited proliferation of non-small cell lung carcinoma cell lines harboring MET amplification in culture (PMID: 26090892). 26090892

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Clinical Trial Phase Therapies Title Recruitment Status


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