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|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|GSK1059615||mTOR Inhibitor 51 PI3K Inhibitor (Pan) 37||GSK1059615 is a dual pan-PI3K/mTOR inhibitor, which prevents cell proliferation (PMID: 24900173).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Unknown unknown||head and neck squamous cell carcinoma||not applicable||GSK1059615||Preclinical - Cell line xenograft||Actionable||In a preclinical study, GSK1059615 treatment in a head and neck squamous cell carcinoma cell line resulted in inhibition of both cell growth and cell proliferation and induced necrosis in culture, and inhibited tumor growth in cell line xenograft models (PMID: 28187451).||28187451|
|PIK3CA act mut||Advanced Solid Tumor||sensitive||GSK1059615||Preclinical||Actionable||In a preclinical study, solid tumor cell lines harboring PIK3CA activating mutations demonstrated increased sensitivity to GSK1059615 in culture (Clin Cancer Res October 1, 2008 14; B37).||detail...|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status|