Therapy Detail

Therapy Name CC-90003
Therapy Description

CC-90003 inhibits ERK, which leads to decreased proliferation of ERK-dependent tumor cells and may be effective against KRAS-mutant tumors (PMID: 30275173).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
CC-90003 ERK Inhibitor (pan) 13 CC-90003 inhibits ERK, which leads to decreased proliferation of ERK-dependent tumor cells and may be effective against KRAS-mutant tumors (PMID: 30275173).
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
NRAS mutant Advanced Solid Tumor no benefit CC-90003 Phase I Actionable In a Phase Ia trial, CC-90003 treatment did not result in any objective responses and demonstrated toxicity in advanced solid tumor patients harboring KRAS, NRAS, or BRAF mutations (J Clin Oncol 35, 2017 (suppl; abstr 2577)). detail...
KRAS mutant Advanced Solid Tumor no benefit CC-90003 Phase I Actionable In a Phase Ia trial, CC-90003 treatment did not result in any objective responses and demonstrated toxicity in advanced solid tumor patients harboring KRAS, NRAS, or BRAF mutations (J Clin Oncol 35, 2017 (suppl; abstr 2577)). detail...
BRAF mutant Advanced Solid Tumor no benefit CC-90003 Phase I Actionable In a Phase Ia trial, CC-90003 treatment did not result in any objective responses and demonstrated toxicity in advanced solid tumor patients harboring KRAS, NRAS, or BRAF mutations (AJ Clin Oncol 35, 2017 (suppl; abstr 2577)). detail...
Clinical Trial Phase Therapies Title Recruitment Status
NCT02313012 Phase I CC-90003 Safety and PK Study of CC-90003 in Relapsed/Refractory Solid Tumors Terminated