Therapy Detail

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Therapy Name Aprutumab ixadotin
Synonyms
Therapy Description

BAY1187982 is an FGFR2 antibody conjugated to a toxin, which may promote apoptosis and inhibit tumor growth (NCI Drug Dictionary).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Aprutumab ixadotin BAY1187982|FGFR2-ADC FGFR2 Antibody 3 Aprutumab ixadotin (BAY1187982) is a monoclonal FGFR2 antibody in conjugation with a derivative of auristatin, which may target FGFR2-expressing tumor cells for cytotoxicity (PMID: 27543601).

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FGFR2 dec exp breast cancer resistant Aprutumab ixadotin Preclinical - Cell culture Actionable In a preclinical study, Aprutumab ixadotin (BAY1187982) did not inhibit growth of breast cancer cells with very low Fgfr2 expression level in culture (PMID: 27543601). 27543601
FGFR2 positive stomach cancer sensitive Aprutumab ixadotin Preclinical - Pdx & cell culture Actionable In a preclinical study, Aprutumab ixadotin (BAY1187982) inhibited survival of gastric cancer cell lines with elevated Fgfr2 expression level in culture, and suppressed tumor growth in cell line or patient-derived xenograft models (PMID: 27543601). 27543601
FGFR2 amp ovarian cancer sensitive Aprutumab ixadotin Preclinical - Pdx Actionable In a preclinical study, Aprutumab ixadotin (BAY1187982) inhibited tumor growth in patient-derived xenograft models of FGFR2 amplified ovarian cancer (PMID: 27543601). 27543601
FGFR2 positive breast cancer sensitive Aprutumab ixadotin Preclinical - Pdx & cell culture Actionable In a preclinical study, Aprutumab ixadotin (BAY1187982) inhibited survival of Fgfr2 positive breast cancer cell lines in culture, and suppressed tumor growth in both cell line and patient-derived xenograft models (PMID: 27543601). 27543601
FGFR2 over exp colorectal cancer sensitive Aprutumab ixadotin Preclinical - Cell line xenograft Actionable In a preclinical study, Aprutumab ixadotin (BAY1187982) inhibited survival of colorectal cancer cells with over expressing Fgfr2 in culture, and suppressed tumor growth in cell line xenograft models (PMID: 27543601). 27543601
Unknown unknown Advanced Solid Tumor no benefit Aprutumab ixadotin Phase I Actionable In a Phase I trial, Aprutumab ixadotin (BAY1187982) was poorly tolerated, resulted in no objective response (0/20) and 1 stable disease in patients with advanced solid tumors known to be FGFR2-positive, and the trial was terminated early as a result (PMID: 31502117; NCT02368951). 31502117
FGFR2 positive Advanced Solid Tumor sensitive Aprutumab ixadotin Preclinical - Pdx & cell culture Actionable In a preclinical study, sensitivity to Aprutumab ixadotin (BAY1187982) positively correlated with Fgfr2 expression level in a variety of cancer cell lines in culture, and in cell line or patient-derived xenograft models (PMID: 27543601). 27543601

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Clinical Trial Phase Therapies Title Recruitment Status
NCT02368951 Phase I Aprutumab ixadotin Phase I, Dose-escalation Trial of BAY1187982 in Subjects With Advanced Solid Tumors Known to Express Fibroblast Growth Factor Receptor 2 (FGFR2) Terminated


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