Therapy Detail

Therapy Name Chlorambucil
Therapy Description


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Drug Name Trade Name Synonyms Drug Classes Drug Description
Chlorambucil Ambochlorin Chlocambucil
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
BRCA2 del colorectal adenocarcinoma sensitive Chlorambucil Preclinical Actionable In a preclinical study, colorectal adenocarcinoma cells with BRCA2 deletion demonstrated increased sensitivity to Ambochlorin (chlorambucil) compared to cells with intact BRCA2 in culture (PMID: 25193512). 25193512
BRCA1 dec exp triple-receptor negative breast cancer sensitive Chlorambucil Preclinical Actionable In a preclinical study, BRCA1 knockdown enhanced growth inhibition by Ambochlorin (chlorambucil) in triple-receptor negative breast cancer cell lines in culture (PMID: 25193512). 25193512