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|Therapy Name||Paclitaxel + Plicamycin|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|Paclitaxel||Taxol||7-Epipaclitaxel||Antimicrotubule Agent 12 BCL2 Family Inhibitor 6||Taxol (paclitaxel) binds to tubulin to inhibit microtubule disassembly, which results in decreased cell division, and also binds to the anti-apoptotic factor Bcl-2, promoting apoptosis (NCI Drug Dictionary).|
|Plicamycin||Mithracin||Mithramycin||Antibiotic Antineoplastic 1||Mithracin (plicamycin) is an antineoplastic antibiotic, which binds to DNA and prevents cells from making RNA and proteins (NCI Drug Dictionary).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Unknown unknown||triple-receptor negative breast cancer||not applicable||Paclitaxel + Plicamycin||Preclinical||Actionable||In a preclinical study, Mithracin (plicamycin) and Taxol (paclitaxel) worked synergistically to inhibit the growth of triple-receptor negative breast cancer cell lines in culture (PMID: 20576088).||20576088|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status|