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Therapy Name Radiotherapy
Synonyms
Therapy Description

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Radiotherapy

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
ATM inact mut Advanced Solid Tumor predicted - sensitive Radiotherapy Clinical Study Actionable In a clinical study, treatment with radiotherapy resulted in greater therapeutic efficacy in advanced solid tumor patients harboring an ATM inactivating mutation (n=177) compared to those who harbored an ATM variant of unknown significance (n=180), demonstrating a significantly decreased 2-year cumulative incidence of irradiated progression, 13.2% versus 27.5% (p=0.001), respectively, and the greatest clinical benefit was observed in tumors with bi-allelic ATM inactivating mutations (PMID: 32726432). 32726432
ATM Q1331H ATM I1441fs lung non-small cell carcinoma predicted - sensitive Radiotherapy Case Reports/Case Series Actionable In a retrospective analysis, radiotherapy treatment resulted in 3.1 months of local disease control and no in-field recurrence in a patient with non-small cell lung cancer harboring ATM I1441fs and Q1331H (PMID: 28055970). 28055970
ATM R1898* colon cancer predicted - sensitive Radiotherapy Case Reports/Case Series Actionable In a retrospective analysis, radiotherapy treatment resulted in 3.9 months of local disease control and no in-field recurrence in a patient with colon cancer harboring ATM R1898* (PMID: 28055970). 28055970
ATM I1453fs tongue squamous cell carcinoma predicted - sensitive Radiotherapy Case Reports/Case Series Actionable In a retrospective analysis, radiotherapy treatment resulted in a complete metabolic response lasting at least 34 months in a patient with squamous cell carcinoma of the tongue, and the patient was found to harbor ATM I1453fs (PMID: 28055970). 28055970
ATM R1875* colon cancer predicted - sensitive Radiotherapy Case Reports/Case Series Actionable In a retrospective analysis, radiotherapy treatment resulted in 3.8 months of local disease control and no in-field recurrence in a patient with colon cancer harboring ATM R1875* (PMID: 28055970). 28055970
ATM L2738* thyroid cancer predicted - sensitive Radiotherapy Case Reports/Case Series Actionable In a retrospective analysis, radiotherapy treatment resulted in 5.16 months of local disease control and no in-field recurrence in a patient with thyroid cancer harboring ATM L2738* (PMID: 28055970). 28055970

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT01898104 Phase Ib/II Capecitabine + Radiotherapy Radiotherapy + Valproic acid Capecitabine + Radiotherapy + Valproic acid Radiotherapy Preoperative Valproic Acid and Radiation Therapy for Rectal Cancer (V-shoRT-R3) Recruiting ITA 0
NCT01928589 Phase Ib/II Radiotherapy Partial Irradiation and Sequential vs. Concurrent Chemo Early Breast Cancer Active, not recruiting USA 0


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