Therapy Detail

Therapy Name Gemcitabine + SRA737
Synonym
Therapy Description

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Gemcitabine Gemzar Difluorodeoxycytidine Hydrochlorothiazide Chemotherapy - Antimetabolite 10 Gemzar (gemcitabine) is converted in cells to difluorodeoxycytidine di- and triphosphate (dFdCDP, dFdCTP), which act to inhibit ribonucleoside reductase and as a deoxynucleotide analog respectively, resulting in DNA strand termination and apoptosis (NCI Drug Dictionary).
SRA737 CCT245737 CHK1 Inhibitor 14 SRA737 (CCT245737) is a selective oral inhibitor of CHK1, which may enhance sensitivity of tumor cells to chemotherapeutics, thereby resulting in increased antitumor activity (PMID: 27167172).
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
KRAS G12D TP53 R175H pancreatic ductal adenocarcinoma sensitive Gemcitabine + SRA737 Preclinical Actionable In a preclinical study, Gemzar (gemcitabine) resulted in enhanced antitumor efficacy, including decreased tumor volume, when combined with SRA737 (CCT245737) in a pancreatic ductal adenocarcinoma transgenic mouse model harboring KRAS G12D and TP53 R175H (PMID: 27167172). 27167172
Unknown unknown colon cancer not applicable Gemcitabine + SRA737 Preclinical - Cell line xenograft Actionable In a preclinical study, Gemzar (gemcitabine) resulted in enhanced antitumor efficacy when combined with SRA737 (CCT245737) in a colon cancer cell line xenograft model (PMID: 27167172). 27167172
Unknown unknown lung non-small cell carcinoma not applicable Gemcitabine + SRA737 Preclinical - Cell line xenograft Actionable In a preclinical study, a non-small cell lung carcinoma cell line demonstrated sensitivity to the combination of SRA737 (CCT245737) and Gemzar (gemcitabine), resulting in antitumor efficacy in both culture and xenograft models (PMID: 27167172). 27167172
Clinical Trial Phase Therapies Title Recruitment Status