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|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|LSN3074753||RAF Inhibitor (Pan) 20||LSN3074753 is a pan-RAF inhibitor that inhibits signaling of all RAF isoforms and RAF dimers, which leads to inhibition of tumor cell growth (PMID: 28611205).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|BRAF mutant||colorectal cancer||predicted - sensitive||LSN3074753||Preclinical - Pdx||Actionable||In a preclinical study, LSN3074753 resulted in a disease control rate of 8.3% (1/12) in BRAF mutant patient-derived xenograft models of colorectal cancer (PMID: 28611205).||28611205|
|BRAF V600E||colorectal cancer||predicted - sensitive||LSN3074753||Preclinical - Pdx||Actionable||In a preclinical study, LSN3074753 demonstrated modest efficacy in patient-derived xenograft models of colorectal cancer harboring BRAF V600E, resulted in tumor growth inhibition or regression, but relapse upon discontinuation of treatment (PMID: 28611205).||28611205|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|