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Therapy Name | WX-0593 |
Synonyms | |
Therapy Description |
WX-0593 inhibits Alk and Egfr, which may lead to tumor growth inhibition (Cancer Res 2018;78(13 Suppl):Abstract nr 4794). |
Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
---|---|---|---|---|
WX-0593 | WX0593|WX 0593|FL 006|FL-006|FL006 | ALK Inhibitor 23 EGFR Inhibitor (Pan) 47 | WX-0593 (FL 006) inhibits Alk and Egfr, which may lead to tumor growth inhibition (Cancer Res 2018;78(13 Suppl):Abstract nr 4794). |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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EML4 - ALK ALK L1196M | Advanced Solid Tumor | sensitive | WX-0593 | Preclinical - Cell culture | Actionable | In a preclinical study, WX-0593 inhibited growth of transformed cells expressing ALK L1196M in the context of EML4-ALK in culture (Cancer Res 2018;78(13 Suppl):Abstract nr 4794). | detail... |
EML4 - ALK ALK C1156Y | Advanced Solid Tumor | sensitive | WX-0593 | Preclinical - Cell culture | Actionable | In a preclinical study, WX-0593 inhibited growth of transformed cells expressing ALK C1156Y in the context of EML4-ALK in culture (Cancer Res 2018;78(13 Suppl):Abstract nr 4794). | detail... |
EML4 - ALK | Advanced Solid Tumor | sensitive | WX-0593 | Preclinical - Cell culture | Actionable | In a preclinical study, WX-0593 inhibited growth of transformed cells expressing EML4-ALK in culture (Cancer Res 2018;78(13 Suppl):Abstract nr 4794). | detail... |
EML4 - ALK | lung non-small cell carcinoma | sensitive | WX-0593 | Preclinical - Pdx | Actionable | In a preclinical study, WX-0593 inhibited Alk downstream signaling and tumor growth in patient-derived xenograft (PDX) models of non-small cell lung cancer harboring EML4-ALK (Cancer Res 2018;78(13 Suppl):Abstract nr 4794). | detail... |
Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
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