Therapy Detail
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| Therapy Name | Vepdegestrant |
| Synonyms | |
| Therapy Description |
Vepdegestrant (ARV-471) is a bifunctional molecule that targets the estrogen receptor (ESR1), including ESR1 variants, for proteolytic degradation resulting in reduced target gene expression and potentially leading to reduced cell proliferation and inhibition of tumor growth (Cancer Res 2019;79(4 Suppl):Abstract nr P5-04-18, PMID: 32829249). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Vepdegestrant | ARV471|ARV 471|PF 07850327|PF07850327|PF-07850327|ARV-471 | Hormone - Anti-estrogens 25 | Vepdegestrant (ARV-471) is a bifunctional molecule that targets the estrogen receptor (ESR1), including ESR1 variants, for proteolytic degradation resulting in reduced target gene expression and potentially leading to reduced cell proliferation and inhibition of tumor growth (Cancer Res 2019;79(4 Suppl):Abstract nr P5-04-18, PMID: 32829249). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT04072952 | Phase Ib/II | Palbociclib + Vepdegestrant Vepdegestrant | A Phase 1/2 Trial of ARV-471 Alone and in Combination With Palbociclib (IBRANCE®) in Patients With ER+/HER2- Locally Advanced or Metastatic Breast Cancer (mBC) | Recruiting | USA | 0 |
| NCT05549505 | Phase II | Anastrozole Vepdegestrant | A Trial Using ARV-471 or Anastrozole in Post-Menopausal Women With Breast Cancer Prior to Surgery | Active, not recruiting | USA | ESP | DEU | 1 |
| NCT05654623 | Phase III | Fulvestrant Vepdegestrant | A Study to Learn About a New Medicine Called ARV-471 (PF-07850327) in People Who Have Advanced Metastatic Breast Cancer. (VERITAC-2) | Recruiting | USA | ITA | GBR | FRA | ESP | DEU | CAN | BEL | AUS | 21 |
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