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Therapy Name ARV-471
Synonyms
Therapy Description

ARV-471 is a bifunctional molecule that targets the estrogen receptor (ESR1), including ESR1 variants, for proteolytic degradation resulting in reduced target gene expression and potentially leading to reduced cell proliferation and inhibition of tumor growth (Cancer Res 2019;79(4 Suppl):Abstract nr P5-04-18, PMID: 32829249).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
ARV-471 ARV471|ARV 471 Hormone - Anti-estrogens 25 ARV-471 is a bifunctional molecule that targets the estrogen receptor (ESR1), including ESR1 variants, for proteolytic degradation resulting in reduced target gene expression and potentially leading to reduced cell proliferation and inhibition of tumor growth (Cancer Res 2019;79(4 Suppl):Abstract nr P5-04-18, PMID: 32829249).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT04072952 Phase Ib/II ARV-471 + Palbociclib ARV-471 A Phase 1/2 Trial of ARV-471 Alone and in Combination With Palbociclib (IBRANCE®) in Patients With ER+/HER2- Locally Advanced or Metastatic Breast Cancer (mBC) Recruiting USA 0
NCT05549505 Phase II Anastrozole ARV-471 A Trial Using ARV-471 or Anastrozole in Post-Menopausal Women With Breast Cancer Prior to Surgery Recruiting USA | ESP | DEU 1
NCT05654623 Phase III Fulvestrant ARV-471 A Study to Learn About a New Medicine Called ARV-471 (PF-07850327) in People Who Have Advanced Metastatic Breast Cancer. (VERITAC-2) Recruiting USA | ITA | FRA | ESP | DEU | CAN | BEL | AUS 20


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