Therapy Detail

Therapy Name PX-866
Therapy Description

Oncothyreon (PX-866) is a PI3K inhibitor, which inhibits the activation of the PI3K/Akt signaling pathway, thereby inhibiting cancer cell motility and growth (PMID: 17766839).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
PX-866 Oncothyreon PI3K Inhibitor (Pan) 34 Oncothyreon (PX-866) is a PI3K inhibitor, which inhibits the activation of the PI3K/Akt signaling pathway, thereby inhibiting cancer cell motility and growth (PMID: 17766839).
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
KRAS G12D lung adenocarcinoma sensitive PX-866 Preclinical Actionable In a preclinical study, the treatment of KRAS G12D mutant mouse lung cancer with PX-866, a PI3K inhibitor, resulted in inhibition of tumor growth (PMID: 18493606). 18493606
Clinical Trial Phase Therapies Title Recruitment Status