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|Therapy Name||AsiDNA + AZD2461|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|AZD2461||PARP Inhibitor (Pan) 20||AZD2461 inhibits PARP1 and PARP2, resulting in decreased tumor cell growth (PMID: 27550455, PMID: 28332364).|
|AsiDNA||AsiDNA is an oligodeoxyribonucleotide drug that acts as a DNA repair pathway antagonist by mimicking double-stranded DNA breaks and subsequently recruiting DNA repair proteins, thereby preventing the repair of other DNA damaged sites, and thus, potentially leading to increased cell death and inhibition of cell proliferation (PMID: 27559053, PMID: 32839491).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Unknown unknown||breast cancer||not applicable||AsiDNA + AZD2461||Preclinical - Cell culture||Actionable||In a preclinical study, AsiDNA and AZD2461 combination treatment resulted in increased cell death and inhibition of proliferation in breast cancer cell lines compared to AZD2461 alone in culture (PMID: 27559053).||27559053|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status|