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|Therapy Name||JQ1 + PF-3758309|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|JQ1||BET Inhibitor (Pan) 27||JQ1 is a BET bromodomain inhibitor with greatest specificity towards BRD4, resulting in decreased Myc expression, increased cell death, reduced macrophage immunosuppression, and inhibition of tumor growth (PMID: 24231268, PMID: 31018997, PMID: 30906568).|
|PF-3758309||Pak-I Inhibitor 4||PF-3758309 is a p21-activated kinase (PAK) inhibitor with activity against PAK1 and PAK4, potentially resulting in decreased tumor growth (PMID: 20439741, PMID: 23543898, PMID: 32469945, PMID: 31312349).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status|