Therapy Detail

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Therapy Name TT-00420
Synonyms
Therapy Description

TT-00420 inhibits AURKA and AURKB, potentially resulting in decreased tumor growth (Cancer Res July 1 2018 (78) (13 Supplement) 5869).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
TT-00420 TT00420|TT 00420 Aurka Inhibitors 24 Aurkb Inhibitors 20 TT-00420 inhibits AURKA and AURKB, potentially resulting in decreased tumor growth (Cancer Res July 1 2018 (78) (13 Supplement) 5869).

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT04919642 Phase II TT-00420 Study to Evaluate the Efficacy and Safety of TT-00420 in Cholangiocarcinoma Recruiting USA 0
NCT03654547 Phase I TT-00420 Safety of TT-00420 Monotherapy in Patients With Advanced Solid Tumors and Triple Negative Breast Cancer Active, not recruiting USA 1
NCT04742959 Phase Ib/II TT-00420 Nab-paclitaxel + TT-00420 Study of TT-00420 Tablet as Monotherapy and Combination Therapy in Patients With Advanced Solid Tumors Recruiting USA 0


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