Disease Detail

ID DOID:3073
Name brain glioblastoma multiforme
Definition A brain glioma that has_material_basis_in abnormally proliferating cells derives_from glial cells, has_symptom seizure, headaches, nausea and vomiting, memory loss, changes to personality, mood or concentration; and localized neurological problems.
Source DiseaseOntology.org
Alt Ids
Path disease disease of cellular proliferation cancer organ system cancer nervous system cancer central nervous system cancer brain cancer brain glioma brain glioblastoma multiforme

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Molecular Profile Therapy Indication/Tumor Type Response Type Profile Response Detail
Unknown unknown Irinotecan + Sirolimus + Sunitinib + Temozolomide brain glioblastoma multiforme not applicable detail...
Unknown unknown Axitinib brain glioblastoma multiforme not applicable detail...
CDKN2A loss Milciclib brain glioblastoma multiforme sensitive detail...
Clinical Trial Phase Therapies Title Recruitment Status
NCT01112527 Phase II Dacomitinib PF-00299804 in Adult Patients With Relapsed/Recurrent Glioblastoma Completed
NCT01837862 Phase Ib/II Carboplatin + Mebendazole + Temozolomide + Vincristine Bevacizumab + Irinotecan + Mebendazole A Phase I/II Study of Mebendazole for the Treatment of Pediatric Gliomas Recruiting
NCT01891747 Phase Ib/II Bevacizumab + Temozolomide A Phase I/II Study of High-dose L-methylfolate in Combination With Temozolomide and Bevacizumab in Recurrent High Grade Glioma Active, not recruiting
NCT01954576 Phase II NovoTTF Therapy in Treating Patients With Recurrent Glioblastoma Multiforme Recruiting
NCT02052648 Phase Ib/II Temozolomide Indoximod Study of IDO Inhibitor and Temozolomide for Adult Patients With Primary Malignant Brain Tumors Active, not recruiting
NCT03522298 Phase II GDC-0084 Safety, Pharmacokinetics and Efficacy of GDC-0084 in Newly-diagnosed Glioblastoma Multiforme Recruiting