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ID DOID:7497
Name brain ependymoma
Definition A brain glioma that is characterized by tumor of the ependyma, has_material_basis_in abnormally proliferating cells derives_from ependymal cells, located_in spine in adults and located_in intracranial (4th ventricle) in children.
Source DiseaseOntology.org
Alt Ids
Path disease disease of cellular proliferation cancer organ system cancer nervous system cancer central nervous system cancer brain cancer brain glioma brain ependymoma


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Molecular Profile Therapy Indication/Tumor Type Response Type Profile Response Detail
Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT01096368 Phase III Carboplatin + Cyclophosphamide + Vincristine sulfate liposome Carboplatin + Etoposide + Vincristine sulfate liposome Cisplatin + Cyclophosphamide + Etoposide Cisplatin + Cyclophosphamide + Etoposide + Vincristine sulfate liposome Maintenance Chemotherapy or Observation Following Induction Chemotherapy and Radiation Therapy in Treating Patients With Newly Diagnosed Ependymoma Active, not recruiting USA | NZL | CAN | AUS 0
NCT01295944 Phase II Bevacizumab + Carboplatin Carboplatin and Bevacizumab for Recurrent Ependymoma Completed USA 0
NCT02458339 Phase I Methotrexate Methotrexate Infusion Into Fourth Ventricle in Children With Recurrent Malignant Fourth Ventricular Brain Tumors Completed USA 0
NCT03434262 Phase I Ribociclib + Trametinib Filgrastim + Gemcitabine + Ribociclib Ribociclib + Sonidegib SJDAWN: St. Jude Children's Research Hospital Phase 1 Study Evaluating Molecularly-Driven Doublet Therapies for Children and Young Adults With Recurrent Brain Tumors Completed USA 0
NCT03698994 Phase II Ulixertinib Ulixertinib in Treating Patients With Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With MAPK Pathway Mutations (A Pediatric MATCH Treatment Trial) Active, not recruiting USA 1
NCT03727841 Phase II Marizomib Marizomib for Recurrent Low-Grade and Anaplastic Supratentorial, Infratentorial, and Spinal Cord Ependymoma Terminated USA 0
NCT03838042 Phase Ib/II Entinostat + Nivolumab INFORM2 Study Uses Nivolumab and Entinostat in Children and Adolescents With High-risk Refractory Malignancies (INFORM2 NivEnt) Recruiting NLD | FRA | DEU | AUT | AUS 2
NCT04732065 Phase I ONC206 ONC206 for Treatment of Newly Diagnosed or Recurrent Diffuse Midline Gliomas, and Other Recurrent Malignant Brain Tumors (PNOC 023) Recruiting USA 1
NCT04903080 Phase I HER2 CAR-T cells HER2-specific Chimeric Antigen Receptor (CAR) T Cells for Children With Ependymoma Recruiting USA 0
NCT04958486 Phase I Azacitidine + Trastuzumab Combination Intraventricular Chemotherapy Pilot Study: 5-Azacytidine (5-AZA) and Trastuzumab Infusions Into the Fourth Ventricle or Resection Cavity in Children and Adults With Recurrent or Residual Posterior Fossa Ependymoma Recruiting USA 0
NCT05106296 Phase I Cyclophosphamide + Etoposide + Ibrutinib + Indoximod Chemo-immunotherapy Using Ibrutinib Plus Indoximod for Patients With Pediatric Brain Cancer Recruiting USA 0
NCT05169944 Phase I Hu5F9-G4 Magrolimab in Children and Adults With Recurrent or Progressive Malignant Brain Tumors (PNOC025) Suspended USA 0
NCT05887882 Phase I TGF-beta-imprinted NK cells Intra-Tumoral Injections of Natural Killer Cells for Recurrent Malignant Brain Tumors (PNOC028) Recruiting USA 0