Drug Detail


Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Drug Name RO4929097
Trade Name
Synonyms RG-4733
Drug Descriptions

RO4929097 (RG-4733) is a gamma secretase inhibitor, which blocks Notch cleavage and activation, and may inhibit angiogenesis and tumor growth (PMID: 19773430, PMID: 31953695).

DrugClasses Gamma secretase inhibitor 13
CAS Registry Number 847925-91-1
NCIT ID C88333


  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")


  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
Carboplatin + Paclitaxel + RO4929097 Carboplatin Paclitaxel RO4929097 0 0
Paclitaxel + RO4929097 Paclitaxel RO4929097 0 0
Radiotherapy + RO4929097 + Temozolomide RO4929097 Radiotherapy Temozolomide 0 0
RO4929097 RO4929097 0 1
RO4929097 + Vismodegib RO4929097 Vismodegib 0 1

Additional content available in CKB BOOST