Drug Detail


Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Drug Name Fruquintinib
Trade Name Fruzaqla
Synonyms HMPL-013
Drug Descriptions

Fruzaqla (fruquintinib) binds and inhibits VEGFR1/2/3, potentially resulting in reduced cell proliferation and decreased tumor growth (PMID: 25482937, PMID: 31790382). Fruzaqla (fruquintinib) is FDA approved for use in patients with metastatic colorectal cancer who have received prior therapy (FDA.gov).

DrugClasses VEGFR Inhibitor (Pan) 36
CAS Registry Number 1194506-26-7
NCIT ID C102852


  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")


  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
Ensartinib + Fruquintinib Ensartinib Fruquintinib 0 0
Fruquintinib Fruquintinib 0 2
Fruquintinib + Paclitaxel Fruquintinib Paclitaxel 0 0
Fruquintinib + Sintilimab Fruquintinib Sintilimab 0 0
Fruquintinib + Tislelizumab Fruquintinib Tislelizumab 0 1

Additional content available in CKB BOOST