Drug Detail


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Drug Name TTX-030
Trade Name
Synonyms TTX030|TTX 030
Drug Descriptions

TTX-030 is a monoclonal antibody that binds to and inhibits soluble and membrane-bound ENTPD1 (CD39), resulting in decreased ATP hydrolysis, which potentially leads to activation of T-lymphocytes and anti-tumor immune response (AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 5012).

DrugClasses Adenosine Targeting 20 CD39 Antibody 3
CAS Registry Number NA
NCIT ID C162693


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Therapy Name Drugs Efficacy Evidence Clinical Trials
ABBV-181 + Fluorouracil + Leucovorin + Oxaliplatin + TTX-030 ABBV-181 Fluorouracil Leucovorin Oxaliplatin TTX-030 0 0
Docetaxel + TTX-030 Docetaxel TTX-030 0 1
Gemcitabine + Nab-paclitaxel + TTX-030 Gemcitabine Nab-paclitaxel TTX-030 0 1
Pembrolizumab + TTX-030 Pembrolizumab TTX-030 0 1
TTX-030 TTX-030 0 1

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