Gene Detail

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Gene Symbol MAP2K1
Synonyms CFC3 | MAPKK1 | MEK1 | MEL | MKK1 | PRKMK1
Gene Description MAP2K1 (MEK1), mitogen-activated protein kinase kinase 1, is a serine-threonine kinase, which activates that RAS-RAF-MEK-ERK pathway in cell proliferation and differentiation (PMID: 22753777). MAP2K1 (MEK1) activating mutations have been identified in a number of solid tumor types including, melanoma (PMID: 29753091), colorectal (PMID: 28819429), lung adenocarcinoma (PMID: 25351745, PMID: 32361034), histiocytic sarcoma (PMID: 29768143), and Map2k1 mutations are often associated with resistance to Mek and Raf inhibition (PMID: 29753091).

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Molecular Profile Protein Effect Treatment Approaches
MAP2K1 A106T no effect - predicted
MAP2K1 A106_I107del gain of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor
MAP2K1 A132V unknown
MAP2K1 A158T unknown
MAP2K1 A347T unknown
MAP2K1 A390T unknown
MAP2K1 A52V no effect - predicted
MAP2K1 A76fs loss of function - predicted
MAP2K1 A76T unknown
MAP2K1 A95_R96del no effect - predicted
MAP2K1 act mut gain of function MEK inhibitor (Pan) MEK1 Inhibitor
MAP2K1 amp no effect MEK inhibitor (Pan) MEK1 Inhibitor
MAP2K1 C121G unknown
MAP2K1 C121S gain of function
BRAF V600E MAP2K1 C121S
MAP2K1 D136Y unknown
MAP2K1 D190Y no effect - predicted
MAP2K1 D336H no effect - predicted
MAP2K1 D351G unknown
MAP2K1 D351N unknown
MAP2K1 D65N gain of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor
MAP2K1 D67N gain of function MEK inhibitor (Pan) MEK1 Inhibitor
MAP2K1 E102_I103del gain of function
MAP2K1 E114_L115del no effect - predicted
MAP2K1 E120Q gain of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor
MAP2K1 E144K gain of function MEK inhibitor (Pan) MEK1 Inhibitor
MAP2K1 E203D no effect - predicted
MAP2K1 E203K gain of function MEK inhibitor (Pan) MEK1 Inhibitor
BRAF V600E MAP2K1 E203K
MAP2K1 E203Q no effect
MAP2K1 E203V gain of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor
MAP2K1 E320A unknown
MAP2K1 E333A no effect - predicted
MAP2K1 E41_F53del unknown
MAP2K1 E41_L54del gain of function MEK inhibitor (Pan) MEK1 Inhibitor
MAP2K1 E44G no effect
MAP2K1 E51_Q58del gain of function
MAP2K1 F129L gain of function MEK inhibitor (Pan) MEK1 Inhibitor
MAP2K1 F53C gain of function - predicted
MAP2K1 F53I gain of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor
MAP2K1 F53L gain of function MEK inhibitor (Pan) MEK1 Inhibitor
MAP2K1 F53S gain of function MEK inhibitor (Pan) MEK1 Inhibitor
MAP2K1 F53V gain of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor
MAP2K1 F53Y gain of function - predicted
MAP2K1 F53_Q58del gain of function MEK inhibitor (Pan) MEK1 Inhibitor
MAP2K1 F53_Q58delinsL unknown
MAP2K1 F68L unknown
MAP2K1 fusion unknown
MAP2K1 G128C unknown
MAP2K1 G128D gain of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor
MAP2K1 G128N no effect - predicted
MAP2K1 G128R unknown
MAP2K1 G128V unknown
BRAF V600E MAP2K1 G128V
MAP2K1 G294E unknown
MAP2K1 G294R no effect - predicted
MAP2K1 G301* unknown
MAP2K1 G79V unknown
MAP2K1 G80S unknown
MAP2K1 H100_L101del no effect - predicted
MAP2K1 H119P unknown
BRAF V600E MAP2K1 H119P
MAP2K1 H119Q gain of function - predicted
MAP2K1 H119Y gain of function - predicted
MAP2K1 I103N gain of function - predicted
BRAF V600E MAP2K1 I103N
MAP2K1 I103_K104del gain of function MEK inhibitor (Pan) MEK1 Inhibitor
MAP2K1 I104_P105del gain of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor
MAP2K1 I107_R108del gain of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor
MAP2K1 I111A gain of function - predicted
MAP2K1 I111N gain of function - predicted
BRAF V600E MAP2K1 I111N
MAP2K1 I111P gain of function - predicted
MAP2K1 I111R gain of function - predicted
MAP2K1 I111S gain of function
MAP2K1 I111_I112del gain of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor
MAP2K1 I112_R113del gain of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor
MAP2K1 I204T gain of function MEK inhibitor (Pan) MEK1 Inhibitor
MAP2K1 I310L no effect - predicted
MAP2K1 I99G gain of function - predicted
BRAF V600E MAP2K1 I99G
MAP2K1 I99M unknown
BRAF V600E MAP2K1 I99M
MAP2K1 I99T gain of function - predicted
BRAF V600E MAP2K1 I99T
MAP2K1 I99_K104del gain of function
MAP2K1 I9Sfs*3 loss of function - predicted
MAP2K1 inact mut loss of function
MAP2K1 K35N no effect - predicted
MAP2K1 K4N unknown
MAP2K1 K57C gain of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor
MAP2K1 K57E gain of function
BRAF V600E MAP2K1 K57E
MAP2K1 K57M gain of function
MAP2K1 K57N gain of function MEK inhibitor (Pan) MEK1 Inhibitor
ALK rearrange MAP2K1 K57N
EML4 - ALK MAP2K1 K57N
MAP2K1 K57T gain of function
BRAF V600E MAP2K1 K57T
MAP2K1 K57_G61del gain of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor
MAP2K1 K59del unknown MEK inhibitor (Pan) MEK1 Inhibitor
BRAF V600E MAP2K1 K59del
MAP2K1 K97M loss of function
MAP2K1 K97_L98del no effect - predicted
MAP2K1 L101_E102del gain of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor
MAP2K1 L115A gain of function - predicted
MAP2K1 L115P gain of function
BRAF V600E MAP2K1 L115P
MAP2K1 L115R unknown
MAP2K1 L177M gain of function
MAP2K1 L177V gain of function - predicted
MAP2K1 L235H no effect - predicted
MAP2K1 L313F no effect - predicted
MAP2K1 L37P gain of function MEK inhibitor (Pan) MEK1 Inhibitor
MAP2K1 L42F no effect
MAP2K1 L98_I103del gain of function
MAP2K1 L98_K104delinsQ gain of function
MAP2K1 M146I no effect - predicted
MAP2K1 M146T no effect - predicted
MAP2K1 mutant unknown
MAP2K1 N109_Q110del gain of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor
MAP2K1 N109_R113del gain of function MEK inhibitor (Pan) MEK1 Inhibitor
MAP2K1 N122D gain of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor
MAP2K1 N382H unknown
MAP2K1 P105_A106del gain of function MEK inhibitor (Pan) MEK1 Inhibitor
MAP2K1 P105_I107del unknown
MAP2K1 P105_I107delinsL gain of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor
MAP2K1 P124L gain of function
BRAF V600K MAP2K1 P124L
BRAF V600E MAP2K1 P124L
MAP2K1 P124Q unknown
BRAF V600K MAP2K1 P124Q
BRAF V600E MAP2K1 P124Q
MAP2K1 P124R gain of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor
MAP2K1 P124S unknown
BRAF V600E MAP2K1 P124S
ETV6 - NTRK3 MAP2K1 P124S
BRAF V600E MAP2K1 P162S
MAP2K1 P162S unknown
MAP2K1 P193S no effect - predicted
MAP2K1 P264R no effect - predicted
MAP2K1 P264S no effect - predicted
MAP2K1 P306H gain of function MEK inhibitor (Pan) MEK1 Inhibitor
MAP2K1 P321H no effect - predicted
MAP2K1 P323A no effect - predicted
MAP2K1 P387S gain of function
BRAF V600E MAP2K1 P387S NRAS A146T
BRAF V600E MAP2K1 P387S NRAS Q61K
BRAF V600E MAP2K1 P387S NRAS Q61K NRAS A146T
MAP2K1 Q110_I111del gain of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor
MAP2K1 Q164E no effect - predicted
MAP2K1 Q354H unknown
MAP2K1 Q56P gain of function MEK inhibitor (Pan) MEK1 Inhibitor
BRAF V600E MAP2K1 Q56P
BRAF V600E MAP2K1 Q56P NRAS Q61R
MAP2K1 Q56_V60del gain of function MEK inhibitor (Pan) MEK1 Inhibitor
MAP2K1 Q58H no effect - predicted
MAP2K1 Q58_E62del gain of function MEK inhibitor (Pan) MEK1 Inhibitor
MAP2K1 R108Q no effect - predicted
MAP2K1 R108_N109del gain of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor
MAP2K1 R113_E114del no effect - predicted
MAP2K1 R201C no effect - predicted
MAP2K1 R201H no effect - predicted
MAP2K1 R227K no effect - predicted
MAP2K1 R260M unknown
MAP2K1 R349K no effect - predicted
MAP2K1 R47Q gain of function MEK inhibitor (Pan) MEK1 Inhibitor
MAP2K1 R49C unknown
MAP2K1 R49H no effect - predicted
MAP2K1 R49L gain of function MEK inhibitor (Pan) MEK1 Inhibitor
MAP2K1 R96K no effect - predicted
MAP2K1 R96_K97del no effect - predicted
MAP2K1 S123P unknown
MAP2K1 S123T gain of function MEK inhibitor (Pan) MEK1 Inhibitor
MAP2K1 S218D gain of function MEK inhibitor (Pan) MEK1 Inhibitor
MAP2K1 S222A no effect - predicted
MAP2K1 S222D unknown
MAP2K1 S327T no effect - predicted
MAP2K1 S331R unknown
MAP2K1 S86A no effect - predicted
MAP2K1 T28I gain of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor
MAP2K1 T55P unknown
MAP2K1 V211A unknown
MAP2K1 V211D gain of function
BRAF V600E MAP2K1 V211D
BRAF K601E MAP2K1 V211D
MAP2K1 V224M unknown
MAP2K1 V258I no effect - predicted
MAP2K1 V60E gain of function
BRAF V600E MAP2K1 V60E
BRAF V600X MAP2K1 V60E NRAS T58I NRAS Q61R
MAP2K1 V60M gain of function MEK inhibitor (Pan) MEK1 Inhibitor
MAP2K1 V93F unknown
MAP2K1 W247* unknown
MAP2K1 wild-type no effect
MAP2K1 Y130C unknown
MAP2K1 Y130H unknown
MAP2K1 Y130N no effect - predicted
MAP2K1 Y134C gain of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor