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Gene FGFR2
Variant F386_A389del
Impact List deletion
Protein Effect no effect - predicted
Gene Variant Descriptions FGFR2 F386_A389del results in the deletion of four amino acids of the Fgfr2 protein from amino acids 386 to 389 (UniProt.org). F386_A389del has not been biochemically characterized, but results in similar cell proliferation and viability levels as wild-type Fgfr2 in cultured cells (PMID: 29533785), and therefore, it is predicted to have no effect on Fgfr2 protein function.
Associated Drug Resistance
Category Variants Paths

FGFR2 mutant FGFR2 F386_A389del

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Transcript NM_000141.5
gDNA chr10:g.121515238_121515249del12
cDNA c.1157_1168del12
Protein p.F386_A389delFLIA
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001144919 chr10:g.121503799_121503810del12 c.1156_1167del12 p.W386_P389delWEFP RefSeq GRCh38/hg38
NM_001144915.1 chr10:g.121503795_121503806del12 c.1158_1169del12 p.E386_R389delEFPR RefSeq GRCh38/hg38
NM_023029 chr10:g.121503795_121503806del12 c.1158_1169del12 p.E386_R389delEFPR RefSeq GRCh38/hg38
NM_001144918.1 chr10:g.121500869_121500880del12 c.1157_1168del12 p.I386_D389delIDKD RefSeq GRCh38/hg38
NM_001144914.1 chr10:g.121500886_121500897del12 c.1157_1168del12 p.A386_V389delAEAV RefSeq GRCh38/hg38
NM_001144913.1 chr10:g.121515240_121515251del12 c.1157_1168del12 p.V386_I389delVFLI RefSeq GRCh38/hg38
XM_024447888.2 chr10:g.121503849_121503860del12 c.1156_1167del12 p.T386_L389delTPML RefSeq GRCh38/hg38
XM_017015923 chr10:g.121503846_121503857del12 c.1156_1167del12 p.P386_A389delPMLA RefSeq GRCh38/hg38
NM_001144916.1 chr10:g.121500875_121500886del12 c.1156_1167del12 p.V386_D389delVGID RefSeq GRCh38/hg38
XM_024447890.1 chr10:g.121503855_121503866del12 c.1156_1167del12 p.A386_P389delADTP RefSeq GRCh38/hg38
XM_006717708.3 chr10:g.121515297_121515308del12 c.1156_1167del12 p.E386_I389delEKEI RefSeq GRCh38/hg38
NM_022970.4 chr10:g.121515240_121515251del12 c.1157_1168del12 p.V386_I389delVFLI RefSeq GRCh38/hg38
NM_001144915 chr10:g.121503795_121503806del12 c.1158_1169del12 p.E386_R389delEFPR RefSeq GRCh38/hg38
NM_001144913 chr10:g.121515240_121515251del12 c.1157_1168del12 p.V386_I389delVFLI RefSeq GRCh38/hg38
NM_022970.3 chr10:g.121515240_121515251del12 c.1157_1168del12 p.V386_I389delVFLI RefSeq GRCh38/hg38
XM_017015924.3 chr10:g.121500933_121500944del12 c.1156_1167del12 p.T386_K389delTLGK RefSeq GRCh38/hg38
NM_001144916.2 chr10:g.121500875_121500886del12 c.1156_1167del12 p.V386_D389delVGID RefSeq GRCh38/hg38
XM_024447890.2 chr10:g.121503855_121503866del12 c.1156_1167del12 p.A386_P389delADTP RefSeq GRCh38/hg38
XM_006717711 chr10:g.121503855_121503866del12 c.1156_1167del12 p.A386_P389delADTP RefSeq GRCh38/hg38
XM_006717710.5 chr10:g.121515297_121515308del12 c.1156_1167del12 p.E386_I389delEKEI RefSeq GRCh38/hg38
XM_017015925.3 chr10:g.121500929_121500940del12 c.1158_1169del12 p.K387_G390delKPLG RefSeq GRCh38/hg38
NM_001144917.1 chr10:g.121500872_121500883del12 c.1157_1168del12 p.G386_K389delGIDK RefSeq GRCh38/hg38
NM_001320658.2 chr10:g.121515238_121515249del12 c.1157_1168del12 p.F386_A389delFLIA RefSeq GRCh38/hg38
XM_024447888.1 chr10:g.121503849_121503860del12 c.1156_1167del12 p.T386_L389delTPML RefSeq GRCh38/hg38
XM_006717712 chr10:g.121500935_121500946del12 c.1156_1167del12 p.L386_G389delLTLG RefSeq GRCh38/hg38
NM_001144919.2 chr10:g.121503799_121503810del12 c.1156_1167del12 p.W386_P389delWEFP RefSeq GRCh38/hg38
NM_022970 chr10:g.121515240_121515251del12 c.1157_1168del12 p.V386_I389delVFLI RefSeq GRCh38/hg38
NM_001320654.2 chr10:g.121496544_121496555del12 c.1156_1167del12 p.M386_L389delMEYL RefSeq GRCh38/hg38
XM_006717710.4 chr10:g.121515297_121515308del12 c.1156_1167del12 p.E386_I389delEKEI RefSeq GRCh38/hg38
NM_000141 chr10:g.121515238_121515249del12 c.1157_1168del12 p.F386_A389delFLIA RefSeq GRCh38/hg38
NM_001144916 chr10:g.121500875_121500886del12 c.1156_1167del12 p.V386_D389delVGID RefSeq GRCh38/hg38
XM_024447891.1 chr10:g.121500935_121500946del12 c.1156_1167del12 p.L386_G389delLTLG RefSeq GRCh38/hg38
NM_000141.5 chr10:g.121515238_121515249del12 c.1157_1168del12 p.F386_A389delFLIA RefSeq GRCh38/hg38
NM_001144914.1 chr10:g.121500886_121500897del12 c.1157_1168del12 p.A386_V389delAEAV RefSeq GRCh38/hg38
XM_006717710 chr10:g.121515297_121515308del12 c.1156_1167del12 p.E386_I389delEKEI RefSeq GRCh38/hg38
NM_001144915.2 chr10:g.121503795_121503806del12 c.1158_1169del12 p.E386_R389delEFPR RefSeq GRCh38/hg38
XM_017015924.2 chr10:g.121500933_121500944del12 c.1156_1167del12 p.T386_K389delTLGK RefSeq GRCh38/hg38
NM_001144918 chr10:g.121500869_121500880del12 c.1157_1168del12 p.I386_D389delIDKD RefSeq GRCh38/hg38
NM_001144917 chr10:g.121500872_121500883del12 c.1157_1168del12 p.G386_K389delGIDK RefSeq GRCh38/hg38
XM_017015925 chr10:g.121500929_121500940del12 c.1158_1169del12 p.K387_G390delKPLG RefSeq GRCh38/hg38
XM_017015920 chr10:g.121515297_121515308del12 c.1156_1167del12 p.E386_I389delEKEI RefSeq GRCh38/hg38
XM_017015925.2 chr10:g.121500929_121500940del12 c.1158_1169del12 p.K387_G390delKPLG RefSeq GRCh38/hg38
NM_001144913.1 chr10:g.121515240_121515251del12 c.1157_1168del12 p.V386_I389delVFLI RefSeq GRCh38/hg38
XM_024447887.1 chr10:g.121503852_121503863del12 c.1156_1167del12 p.D386_M389delDTPM RefSeq GRCh38/hg38
XM_006717708.4 chr10:g.121515297_121515308del12 c.1156_1167del12 p.E386_I389delEKEI RefSeq GRCh38/hg38
NM_023029.2 chr10:g.121503795_121503806del12 c.1158_1169del12 p.E386_R389delEFPR RefSeq GRCh38/hg38
XM_017015920.2 chr10:g.121515297_121515308del12 c.1156_1167del12 p.E386_I389delEKEI RefSeq GRCh38/hg38
NM_000141.4 chr10:g.121515238_121515249del12 c.1157_1168del12 p.F386_A389delFLIA RefSeq GRCh38/hg38
XM_017015921.3 chr10:g.121515295_121515306del12 c.1156_1167del12 p.K386_T389delKEIT RefSeq GRCh38/hg38
NM_001320658.1 chr10:g.121515238_121515249del12 c.1157_1168del12 p.F386_A389delFLIA RefSeq GRCh38/hg38
XM_017015921 chr10:g.121515295_121515306del12 c.1156_1167del12 p.K386_T389delKEIT RefSeq GRCh38/hg38
NM_001144914 chr10:g.121500886_121500897del12 c.1157_1168del12 p.A386_V389delAEAV RefSeq GRCh38/hg38
XM_024447892.1 chr10:g.121479987_121479998del12 c.1156_1167del12 p.L386_Y389delLEQY RefSeq GRCh38/hg38
XM_006717708 chr10:g.121515297_121515308del12 c.1156_1167del12 p.E386_I389delEKEI RefSeq GRCh38/hg38
NM_001320658 chr10:g.121515238_121515249del12 c.1157_1168del12 p.F386_A389delFLIA RefSeq GRCh38/hg38
XM_017015922 chr10:g.121503849_121503860del12 c.1156_1167del12 p.T386_L389delTPML RefSeq GRCh38/hg38
NM_001144919.1 chr10:g.121503799_121503810del12 c.1156_1167del12 p.W386_P389delWEFP RefSeq GRCh38/hg38
XM_024447887.2 chr10:g.121503852_121503863del12 c.1156_1167del12 p.D386_M389delDTPM RefSeq GRCh38/hg38
XM_017015920.3 chr10:g.121515297_121515308del12 c.1156_1167del12 p.E386_I389delEKEI RefSeq GRCh38/hg38
NM_023029.2 chr10:g.121503795_121503806del12 c.1158_1169del12 p.E386_R389delEFPR RefSeq GRCh38/hg38
XM_024447889.1 chr10:g.121503846_121503857del12 c.1156_1167del12 p.P386_A389delPMLA RefSeq GRCh38/hg38
NM_001320654.1 chr10:g.121496544_121496555del12 c.1156_1167del12 p.M386_L389delMEYL RefSeq GRCh38/hg38
NM_001144917.2 chr10:g.121500872_121500883del12 c.1157_1168del12 p.G386_K389delGIDK RefSeq GRCh38/hg38
XM_024447891.2 chr10:g.121500935_121500946del12 c.1156_1167del12 p.L386_G389delLTLG RefSeq GRCh38/hg38
NM_001320654 chr10:g.121496544_121496555del12 c.1156_1167del12 p.M386_L389delMEYL RefSeq GRCh38/hg38
NM_001144918.2 chr10:g.121500869_121500880del12 c.1157_1168del12 p.I386_D389delIDKD RefSeq GRCh38/hg38
XM_017015921.2 chr10:g.121515295_121515306del12 c.1156_1167del12 p.K386_T389delKEIT RefSeq GRCh38/hg38
XM_024447889.2 chr10:g.121503846_121503857del12 c.1156_1167del12 p.P386_A389delPMLA RefSeq GRCh38/hg38
XM_017015924 chr10:g.121500933_121500944del12 c.1156_1167del12 p.T386_K389delTLGK RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FGFR2 mutant Advanced Solid Tumor sensitive Pemigatinib Preclinical - Cell culture Actionable In a preclinical study, a variety of cancer cell lines harboring mutations in FGFR1, FGFR2, and/or FGFR3 demonstrated sensitivity to Pemazyre (pemigatinib) in culture and in cell line xenograft models, resulting in inhibition of tumor growth (Cancer Res 2015;75(15 Suppl):Abstract nr 771). detail...
FGFR2 mutant transitional cell carcinoma predicted - sensitive Cetrelimab + Erdafitinib Phase II Actionable In a Phase II trial, the combination of Balversa (erdafitinib) and Cetrelimab (JNJ-63723283) treatment resulted in an overall response rate of 54.5% (6 complete responses), disease control rate of 79.5%, median duration of response of 11.10 months, median progression-free survival of 10.97 months, and a 12-month overall survival of 68% in patients with metastatic urothelial carcinoma harboring FGFR mutations (J Clin Oncol 41, 2023 (suppl 16; abstr 4504); NCT03473743). detail...
FGFR2 mutant endometrial cancer sensitive PRN1371 Preclinical - Cell culture Actionable In a preclinical study, PRN1371 inhibited proliferation of endometrial cancer cells harboring FGFR2 mutations in culture (AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 1249). detail...
FGFR2 mutant Advanced Solid Tumor predicted - sensitive Debio 1347 Phase I Actionable In a Phase I trial, Debio 1347 treatment resulted in partial response in 10.5% (6/57) and stable disease in 28.1% (16/57) of patients with advanced solid tumors harboring genomic alterations of FGFR1/2/3, including amplifications, fusions, and mutations (PMID: 30745300; NCT01948297). 30745300
FGFR2 mutant cholangiocarcinoma predicted - sensitive Erdafitinib Phase I Actionable In a Phase I trial, Balversa (erdafitinib) treatment resulted in an objective response rate of 27% (3/11) in patients with cholangiocarcinoma harboring FGFR genomic alterations, including 1 with FGFR2 mutation, 2 with FGFR3 mutations, and 8 with FGFR2 fusions (PMID: 31088831; NCT01703481). 31088831
FGFR2 mutant Advanced Solid Tumor predicted - sensitive ICP-192 Phase I Actionable In a Phase I trial, ICP-192 (gunagratinib) was well-tolerated, and resulted in an overall response rate or 33.3% (4/12, 1 complete response, 3 partial response) and a disease control rate of 91.7% (11/12) in patients with advanced solid tumors harboring FGF/FGFR gene aberrations (J Clin Oncol 39, 2021 (suppl 15; abstr 4092); NCT03758664). detail...
FGFR2 mutant endometrial cancer sensitive Infigratinib Preclinical Actionable In a preclinical study, Truseltiq (infigratinib) inhibited the growth of FGFR2-mutated endometrial cancer cells in vitro and in xenograft models (PMID: 23443805). 23443805
FGFR2 mutant breast cancer no benefit Sunitinib Case Reports/Case Series Actionable In a Phase II trial (TAPUR), Sutent (sunitinib) treatment did not meet the predetermined efficacy criteria in metastatic breast cancer patients with FGFR2 amplification (n=2), FGFR2 mutation (including FGFR2 rearrangement) (n=6), or both (n=2), resulting in no objective responses or stable disease of at least 16 weeks, median progression-free survival of 8 weeks, and a median overall survival of 22 weeks (PMID: 38354330; NCT02693535). 38354330
FGFR2 mutant Advanced Solid Tumor predicted - sensitive Erdafitinib Case Reports/Case Series Actionable In a Phase II trial (MATCH), Balversa (erdafitinib) treatment resulted in an objective response rate of 16% (4/25), median progression-free survival of 3.6 months, and median overall survival of 11.0 months in patients with advanced solid tumors harboring FGFR1, FGFR2, or FGFR3 mutations or fusions (PMID: 38603650; NCT02465060). 38603650
FGFR2 mutant intrahepatic cholangiocarcinoma predicted - sensitive Derazantinib Phase II Actionable In a Phase II trial (FIDES-01), Derazantinib (ARQ 087) treatment resulted in an objective response rate of 6.5%, a disease control rate of 58.1%, median progression-free survival of 8.3 months, and a median overall survival of 15.9 months in patients with intrahepatic cholangiocarcinoma harboring an FGFR2 mutation or amplification (Ann Oncol (2022) 33 (suppl_7): S19-S26; NCT03230318). detail...
FGFR2 mutant cholangiocarcinoma sensitive Infigratinib Case Reports/Case Series Actionable In a Phase I trial, a patient with cholangiocarcinoma harboring an FGFR2 mutation demonstrated a decreased tumor burden when treated with Truseltiq (infigratinib) (PMID: 27870574). 27870574