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|Protein Effect||gain of function|
|Gene Variant Descriptions||IDH1 act mut indicates that this variant results in a gain of function in the Idh1 protein. However, the specific amino acid change has not been identified.|
|Associated Drug Resistance|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|IDH1 act mut||chondrosarcoma||sensitive||Ivosidenib||Guideline||Actionable||Tibsovo (ivosidenib) is included in guidelines as systemic therapy for patients with conventional or dedifferentiated chondrosarcoma harboring an IDH1 activating mutation (NCCN.org).||detail...|
|Molecular Profile||Protein Effect||Treatment Approaches|
|IDH1 act mut||gain of function|