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|Molecular Profile||Indication/Tumor Type||Response Type||Relevant Treatment Approaches||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|FLT3 exon 14 ins FLT3 D698N||Advanced Solid Tumor||resistant||Gilteritinib||Preclinical - Cell culture||Actionable||In a preclinical study, transformed cells co-expressing FLT3 ITD and FLT3 D698N were resistant to treatment with Xospata (gilteritinib) in culture (Blood (2019) 134 (Supplement_1): 2672).||detail...|
|FLT3 exon 14 ins FLT3 D698N||Advanced Solid Tumor||resistant||Pexidartinib||Preclinical||Actionable||In a preclinical study, transformed cells expressing FLT3-ITD along with FLT3 D698N were resistant to PLX3397 in culture (PMID: 25847190).||25847190|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status|